Effects of acids, pepsin, bile acids, and trypsin on laryngopharyngeal reflux diseases: physiopathology and therapeutic targets
Y Li, G Xu, B Zhou, Y Tang, X Liu, Y Wu… - European Archives of …, 2022 - Springer
Purpose Laryngopharyngeal reflux disease (LPRD) is a general term for the reflux of
gastroduodenal contents into the laryngopharynx, oropharynx and even the nasopharynx …
gastroduodenal contents into the laryngopharynx, oropharynx and even the nasopharynx …
Bile reflux and hypopharyngeal cancer
Laryngopharyngeal reflux, a variant of gastroesophageal reflux disease, has been
considered a risk factor in the development of hypopharyngeal cancer. Bile acids are …
considered a risk factor in the development of hypopharyngeal cancer. Bile acids are …
The effect of NNK, a tobacco smoke carcinogen, on the miRNA and mismatch DNA repair expression profiles in lung and head and neck squamous cancer cells
Tobacco smoking is a common risk factor for lung cancer and head and neck cancer.
Molecular changes such as deregulation of miRNA expression have been linked to tobacco …
Molecular changes such as deregulation of miRNA expression have been linked to tobacco …
GPR4 signaling is essential for the promotion of acid-mediated angiogenic capacity of endothelial progenitor cells by activating STAT3/VEGFA pathway in patients …
S Ouyang, Y Li, X Wu, Y Wang, F Liu, J Zhang… - Stem Cell Research & …, 2021 - Springer
Background Patients with coronary artery disease (CAD) are characterized by a decline in
vascular regeneration, which is related to the dysfunction of endothelial progenitor cells …
vascular regeneration, which is related to the dysfunction of endothelial progenitor cells …
Pepsin promotes activation of epidermal growth factor receptor and downstream oncogenic pathways, at slightly acidic and neutral pH, in exposed hypopharyngeal …
Pepsin refluxate is considered a risk factor for laryngopharyngeal carcinogenesis. Non-
acidic pepsin was previously linked to an inflammatory and tumorigenic effect on …
acidic pepsin was previously linked to an inflammatory and tumorigenic effect on …
Associations between gastro-oesophageal reflux disease and a range of diseases: an umbrella review of systematic reviews and meta-analyses
JJ Tan, L Li, X Huang, C Yang, X Liang, Y Zhao, J Xie… - BMJ open, 2020 - bmjopen.bmj.com
Objective Numerous meta-analyses have revealed the association between gastro-
oesophageal reflux disease (GORD) and a range of diseases; however, the certainty of the …
oesophageal reflux disease (GORD) and a range of diseases; however, the certainty of the …
The in vivo preventive and therapeutic properties of curcumin in bile reflux‐related oncogenesis of the hypopharynx
Bile at strongly acidic pH exerts a carcinogenic effect on the hypopharynx, based upon
recent pre‐clinical studies that support its role as an independent risk factor. We recently …
recent pre‐clinical studies that support its role as an independent risk factor. We recently …
Targeting STAT3 prevents bile reflux‐induced oncogenic molecular events linked to hypopharyngeal carcinogenesis
The signal transducer and activator of transcription 3 (STAT3) oncogene is a transcription
factor with a central role in head and neck cancer. Hypopharyngeal cells (HCs) exposed to …
factor with a central role in head and neck cancer. Hypopharyngeal cells (HCs) exposed to …
[HTML][HTML] Pepsin and laryngeal and hypopharyngeal carcinomas
CY Yin, SS Zhang, JT Zhong… - Clinical and …, 2021 - synapse.koreamed.org
Laryngeal and hypopharyngeal carcinomas are common malignant tumors of the head and
neck, and the incidence of both is increasing. Laryngopharyngeal reflux refers to the …
neck, and the incidence of both is increasing. Laryngopharyngeal reflux refers to the …
The Role of PARP‐1 and NF‐κB in Bile‐Induced DNA Damage and Oncogenic Profile in Hypopharyngeal Cells
Objectives/Hypothesis We recently documented that acidic bile, a gastroesophageal reflux
content, can cause invasive hypopharyngeal squamous cell carcinoma, by inducing …
content, can cause invasive hypopharyngeal squamous cell carcinoma, by inducing …