Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …

The study of epigenetics has improved our understanding of mechanisms underpinning
gene‐environment interactions and is providing new insights in the pathophysiology of …

Epigenetic regulation of transcription is a collective term that refers to mechanisms known to
regulate gene transcription without changing the underlying DNA sequence. These …

Background Learning the causal structure helps identify risk factors, disease mechanisms,
and candidate therapeutics for complex diseases. However, although complex biological …

Smooth muscles are a specific muscle subtype that is widely identified in the tissues of
internal passageways. This muscle subtype has the capacity for controlled or regulated …

Background: The identification of expression quantitative trait methylation (eQTMs), defined
as associations between DNA methylation levels and gene expression, might help the …

The epigenome is at the intersection of the environment, genotype, and cellular response.
DNA methylation of cytosine nucleotides, the most studied epigenetic modification, has been …

Little information is known about DNA methylation variation in shaping environment‐specific
drought resistance and resilience for tree adaptation. In this study, we leveraged RNA …

Background Genome-wide association studies (GWASs) have identified thousands of
variants associated with asthma and other complex diseases. However, the functional …

DNA methylation signatures in tumors could serve as reliable biomarkers that are accessible
in archival tissues for tracking the epigenetic dynamics shaped by both cancer cells and the …