Drug metabolism and transport, orchestrated by drug-metabolizing enzymes (DMEs) and
drug transporters (DTs), are implicated in drug–drug interactions (DDIs) and adverse drug …

Hydroxylated metabolites in the living body are considered as a potential biomarker of
exposure to emerging contaminations (ECs) and breast cancer, but their formation …

Short-chain chlorinated paraffins (SCCPs), frequently detected in human tissues or organs,
can result in threat to human health by disturbing normal metabolism. However, their …

Aromatic amines, the widely used raw materials in industry, cause long-term exposure to
human bodies. They can be metabolized by cytochrome P450 enzymes to form active …

Cytochrome P450 enzymes (CYPs) are crucial for metabolizing dioxin compounds such as
1, 2, 3, 7, 8-pentachlorodibenzo-p-dioxin (PeCDD). Here we have applied molecular …

The escalating focus on the environmental occurrence and toxicology of emerging pollutants
underscores the imperative need for a profound exploration of their metabolic …

细胞色素P450 酶在生物体内分布广泛, 在有机污染物的代谢中发挥重要作用. N-
亚硝胺类化合物(N-nitrosamines, NAs) 在P450 酶的初始催化作用下, 所生成的亲电化合物易于 …

Tebuconazole (TEB), a prominent chiral triazole fungicide, has been extensively utilized for
plant pathogen control globally. Despite experimental evidence of TEB metabolism in …

Hydroxylated bromodiphenyl ethers (OH-BDEs) have raised great concern due to their
potential endocrine disrupting effects on humans. In vitro experiments have indicated OH …

The emerging brominated flame retardant, 1, 2-dibromo-4-(1, 2-dibromoethyl) cyclohexane
(TBECH), has recently attracted strong interest due to its extensive detection in the …