Breast cancer (BC) undoubtedly is one of the most common type of cancers amongst
women, which causes about 5 million deaths annually. The treatments and diagnostic …

Overexpression and/or mutations of the receptor tyrosine kinase (RTK) subfamilies, such as
epidermal growth factor receptors (EGFR) and vascular endothelial growth factor receptors …

Studies on the expression of cellular glycans are limited by a lack of sensitive tools that can
discriminate specific structural features. Here we describe the development of a robust …

Initially emerging as a highly innovative concept in the late 1990s, the concept of creating
novel binding reagents based on stable protein scaffolds from outside the immunoglobulin …

Recent progress in radiolabeling of macro-and middle-sized molecular probes has been
extending possibilities to use PET molecular imaging for dynamic application to drug …

With the increasing number of identified intracellular drug targets, cytosolic drug delivery has
gained much attention. Despite advances in synthetic drug carriers, however, construction of …

The abnormal expression of epidermal growth factor receptors HER1 (EGFR) and HER2 is
strongly associated with cancer invasion, metastasis, and angiogenesis. Their molecular …

Considering the dilemma between the effective tumor targeting and the avoidance of
potential toxicity, it is desired to design nanoprobes with positive tumor-targeting and good …

Immuno-oncological treatment strategies that target abnormal receptor profiles of tumors are
an increasingly important feature of cancer therapy. Yet, assessing receptor availability (RA) …

Systematic control of in vivo behavior of protein-based therapeutics is considered highly
desirable for improving their clinical outcomes. Modulation of biochemical properties …