Despite the recent advances in drug development, the majority of novel therapeutics have
not been successfully translated into clinical applications. One of the major factors hindering …

Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this
pathway is associated with many diseases including cancer, infection, metabolic disease …

Exosomes are a subset of extracellular vesicles (EVs) that have important roles in
intercellular communication. They contain and carry bioactive molecules within their …

Retinal pigment epithelium (RPE) alterations in age-related macular degeneration occur in
patches, potentially involving long-distance communication between damaged and healthy …

Blood is a rich source of disease biomarkers, which include extracellular vesicles (EVs). EVs
are nanometer-to micrometer-sized spherical particles that are enclosed by a phospholipid …

Extracellular vesicles are a heterogeneous group of cell-derived membranous structures,
which facilitate intercellular communication. Recent studies have highlighted the importance …

Background Uptake of apoptotic cells induces a tolerogenic phenotype in phagocytes and
promotes peripheral tolerance. The highly conserved Annexin core domain, present in all …

Cardiovascular disease remains the leading cause of morbidity and mortality in the world.
Thus, therapeutic interventions to circumvent this growing burden are of utmost importance …

Purpose Aberrant expression of seminal plasma proteins are associated with altered
homeostasis that may affect the fertilizing ability of spermatozoa. However, the precise roles …

Extracellular vesicles are considered a novel therapeutic tool, due to their ability to transfer
their cargoes to target cells. Different strategies to directly load extracellular vesicles with …