Fibrinogen is one of the primary components of the coagulation cascade and rapidly forms
an insoluble matrix following tissue injury. In addition to its important role in hemostasis …

In vitro models of endothelial assembly into microvessels are useful for the study of
angiogenesis and vasculogenesis. In addition, such models may be used to provide the …

Despite the ubiquitous importance of cell contact guidance, the signal-inducing contact
guidance of mammalian cells in an aligned fibril network has defied elucidation. This is due …

Hydrogels are used for 3D in vitro assays and tissue engineering and regeneration
purposes. For a thorough interpretation of this technology, an integral biomechanical …

The synovium of osteoarthritis (OA) patients can be characterized by an abnormal
accumulation of macrophages originating from extravasated monocytes. Since targeting …

Despite the great promise of antibiotic therapy in wound infections, antibiotic resistance
stemming from frequent dosing diminishes drug efficacy and contributes to recurrent …

Type I collagen and fibrin are two essential proteins in tissue regeneration and have been
widely used for the design of biomaterials. While they both form hydrogels via fibrillogenesis …

Cells are known to continuously remodel their local extracellular matrix (ECM) and in a
reciprocal way, they can also respond to mechanical and biochemical properties of their …

Connective tissue mechanics is highly nonlinear, exhibits a strong Poisson's effect, and is
associated with significant collagen fiber re-arrangement. Although the general features of …

Human plasma-derived bilayered skin substitutes have been successfully used by our group
in different skin tissue engineering applications. However, several issues associated with …