A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

S Shi, J Li, X Zhao, Q Liu, SJ Song - Phytochemistry, 2021 - Elsevier
Prenylated flavonoids, a unique class of flavonoids which combine a flavonoid skeleton and
a lipophilic prenyl side-chain, possess great potential biological activities including …

Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer

AA WalyEldeen, S Sabet, HM El-Shorbagy… - Chemico-Biological …, 2023 - Elsevier
The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

Xanthohumol from Hop: Hope for cancer prevention and treatment

S Girisa, Q Saikia, D Bordoloi, K Banik, J Monisha… - IUBMB …, 2021 - Wiley Online Library
Cancer is a major public health concern due to high mortality and poor quality of life of
patients. Despite the availability of advanced therapeutic interventions, most treatment …

Xanthohumol for human malignancies: Chemistry, pharmacokinetics and molecular targets

V Harish, E Haque, M Śmiech, H Taniguchi… - International journal of …, 2021 - mdpi.com
Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence
of Humulus lupulus L.(Hop plant). XH is an important ingredient in beer and is considered a …

Antiangiogenic effect of flavonoids and chalcones: An update

L Mirossay, L Varinská, J Mojžiš - International journal of molecular …, 2017 - mdpi.com
Chalcones are precursors of flavonoid biosynthesis in plants. Both flavonoids and chalcones
are intensively investigated because of a large spectrum of their biological activities. Among …

Synthesis and evaluation of chalcone derivatives as novel sunscreen agent

LW Wijayanti, RT Swasono, W Lee, J Jumina - Molecules, 2021 - mdpi.com
Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the
research to develop sunscreen agent has been increasing. Chalcone is a promising …

Design, synthesis, and bioactivity of chalcone derivatives containing indanone

N Sun, C Gong, Y Zhou, Y Zhang, N Zhang, L Xing… - ACS …, 2023 - ACS Publications
A series of chalcone derivatives containing indanone were designed and synthesized by
aldehyde-ketone condensation and etherification. The activity test demonstrated that the …

Chalcones against the hallmarks of cancer: A mini-review

PS de Souza, GCC Bibá, EDN Melo… - Natural Product …, 2021 - Taylor & Francis
Abstract Chalcones (1, 3-diphenylpropen-1-ones) are a class of flavonoids that have been
shown a broad spectrum of biological activities with therapeutic potential. Naturally …

Prediction of chalcone derivative cytotoxicity activity against MCF-7 human breast cancer cell by Monte Carlo method

S Ahmadi, F Mardinia, N Azimi, M Qomi… - Journal of Molecular …, 2019 - Elsevier
The anticancer activity of chalcones and their analogs is the most important biological
activity of them among their broad spectrum of their biological activity. In this investigation …

Recent Patents on Therapeutic Activities of Xanthohumol: a Prenylated Chalconoid From Hops (Humulus Lupulus L.)

D Aggarwal, SK Upadhyay, R Singh… - Pharmaceutical patent …, 2021 - Taylor & Francis
There is expanding proof that specific natural compounds found in plants have additional
conventional medicinal properties. One such compound is xanthohumol (XN), which is …