Chronic pain is the most common symptom for people who suffer from rheumatoid arthritis
and it affects approximately 1% of the global population. Neuroinflammation in the spinal …

Pain is the most significant impairment and debilitating challenge for patients with bone
metastasis. Therefore, the primary objective of current therapy is to mitigate and prevent the …

Xuelian, as a traditional Chinese ethnodrug, plays an important role in anti‐inflammation,
immunoregulation, promoting blood circulation, and other physiological functions. It has …

Inflammation is an immune response that could lead to serious health problems. Some
steroids and nonsteroidal drugs are capable of relieving inflammatory reactions but may …

The study firstly included the synthesis of aldehyde derivatives by reacting p-hydroxy
benzaldehyde with ethyl chloroacetate to prepare compound (A), then producing the …

BACKGROUND: As an “off-target” effect, cephalosporins can enhance glutamate transporter-
1 expression in astrocytes to recycle glutamate from synaptic cleft, and exhibited analgesic …

Abstract The Renin-Angiotensin System (RAS) plays a critical role in regulating various
physiological processes. Angiotensin (1-7)(Ang-(1-7), an important component of the RAS …

The investigation was performed on 55 male Wistar rats. The pain behaviors were induced
through the formalin (2.5%) subcutaneous administration into the plantar surface of the right …

Contemporary pharmaceutical chemistry faces several challenges in different directions,
including the need for both the potency and specificity of any therapeutic agent. The …

Opioids have been used to treat acute and chronic pain for millennia. It is studied that
prolonged use of opioids may result in neuroinflammation and increased pain sensation …