The endoplasmic reticulum (ER) is a morphologically and functionally diverse organelle
capable of integrating multiple extracellular and internal signals and generating adaptive …

The ubiquitously expressed serum‐and glucocorticoid‐inducible kinase‐1 (SGK1) is
genomically regulated by cell stress (including cell shrinkage) and several hormones …

Although the endoplasmic reticulum (ER) extends throughout axons and axonal ER
dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is …

Stim1 and Orai1 are ubiquitous proteins that have long been known to mediate Ca2+
release-activated Ca2+ (CRAC) current (ICRAC) and store-operated Ca2+ entry (SOCE) …

Shank3, a key molecule related to the development and deterioration of autism, has recently
been found to downregulate in the murine brain after ischemia/reperfusion (I/R). Despite this …

Key points Pharmacological and molecular inhibition of transient receptor potential
melastatin 7 (TRPM7) reduces store‐operated calcium entry (SOCE). Overexpression of …

Stromal interaction molecules (STIM) 1 and 2 are sensors of the calcium concentration in the
endoplasmic reticulum. Depletion of endoplasmic reticulum calcium stores activates STIM …

The interaction between Ca2+ sensors STIM1 and STIM2 and Ca2+ channel-forming protein
ORAI1 is a crucial element of store-operated calcium entry (SOCE) in non-excitable cells …

Stromal interaction molecules (STIMs), including STIM1 and STIM2, are single-pass
transmembrane proteins that are located predominantly in the endoplasmic reticulum (ER) …

Abstract Calcium (Ca 2+) influx is required for the activation and function of all cells in the
immune system. It is mediated mainly by store-operated Ca 2+ entry (SOCE) through Ca 2+ …