Antimicrobial susceptibility testing (AST) is a critical function of the clinical microbiology
laboratory and is essential for optimizing care of patients with infectious diseases …

Introduction Infections due to multidrug-resistant organisms (MDRO) are a serious concern
for public health with high morbidity and mortality. Though many antibiotics have been …

Abstract The Gram-positive cocci Staphylococcus aureus, Streptococcus spp., and
Enterococcus spp. are the most frequent causative organisms of bloodstream infections and …

Background The treatment options for vancomycin-resistant Enterococcus (VRE) are limited.
A combination of daptomycin (DAP) and β-lactam (BL) has been suggested; however …

Vancomycin-resistant enterococci (VRE) are common causes of bloodstream infections
(BSIs) with high morbidity and mortality rates. They are pathogens of global concern with a …

Background VRE infections increased in 2020. High-dose daptomycin (≥ 10 mg/kg) has
shown mortality benefit over other regimens, though daptomycin resistance is increasing …

Abstract Introduction Daptomycin doses 8–12 mg/kg are recommended for susceptible dose-
dependent Enterococcus species. However, data remain limited on safety outcomes of such …

Introduction High-dose daptomycin-based combinations are recommended for vancomycin-
resistant Enterococcus (VRE) bloodstream infection (BSI). Preclinical data have shown a …

Die Kombination von Vancomycin und Piperacillin/Tazobactam (V+ P/T) kommt in der
empirischen Therapie von schweren Infektionen zum Einsatz, insbesondere, wenn …

Background Daptomycin (DAP) is a cyclic lipopeptide antibiotic with in vitro, concentration-
dependent bactericidal activity against many clinically relevant gram-positive organisms …