NLRP3 inflammasome is a multiprotein complex involved in host immune response─ which
exerts various biological effects by mediating the maturation and secretion of IL-1β and IL …

The innate immune system initiates cell death pathways in response to pathogens and
cellular stress. Cell death can be either non-lytic (apoptosis) or lytic (PANoptosis, pyroptosis …

NLRP3 is a molecular sensor recognizing a wide range of danger signals. Its activation
leads to the assembly of an inflammasome that allows for activation of caspase-1 and …

Atherosclerosis, a chronic inflammatory disease characterized by arterial plaque
accumulation, remains a significant global health challenge. In recent years …

Activation of the NLRP3 inflammasome in response to danger signals is a key innate
immune mechanism and results in the production of the pro-inflammatory cytokines …

Gout is an autoinflammatory disorder characterized by the accumulation of monosodium
urate crystals in joints and other tissues, representing the predominant type of inflammatory …

This first‐in‐human study evaluated the safety, tolerability, single‐and multiple‐dose
pharmacokinetic profiles with dietary influence, and pharmacodynamics (PD) of DFV890, an …

The NLRP3 inflammasome plays a central role in the pathogenesis of various intractable
human diseases, making it an urgent target for therapeutic intervention. Here, we report the …

Glioblastoma (GBM) is the deadliest malignant brain tumor, with a survival of less than 14
months after diagnosis. The highly invasive nature of GBM makes total surgical resection …

Aberrant activation of NLRP3 due to persistent tissue damage, misfolded proteins or crystal
deposits has been linked to multiple chronic inflammatory disorders such as cryopyrin …