Emerging structural insights into GPCR–β-arrestin interaction and functional outcomes
Agonist-induced recruitment of β-arrestins (βarrs) to G protein-coupled receptors (GPCRs)
plays a central role in regulating the spatio-temporal aspects of GPCR signaling. Several …
plays a central role in regulating the spatio-temporal aspects of GPCR signaling. Several …
Structural basis of GPCR coupling to distinct signal transducers: implications for biased signaling
M Seyedabadi, M Gharghabi, EV Gurevich… - Trends in biochemical …, 2022 - cell.com
Three classes of G-protein-coupled receptor (GPCR) partners–G proteins, GPCR kinases,
and arrestins–preferentially bind active GPCRs. Our analysis suggests that the structures of …
and arrestins–preferentially bind active GPCRs. Our analysis suggests that the structures of …
Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias
K Kawakami, M Yanagawa, S Hiratsuka… - Nature …, 2022 - nature.com
Signaling-biased ligands acting on G-protein-coupled receptors (GPCRs) differentially
activate heterotrimeric G proteins and β-arrestins. Although a wealth of structural knowledge …
activate heterotrimeric G proteins and β-arrestins. Although a wealth of structural knowledge …
Structural snapshots uncover a key phosphorylation motif in GPCRs driving β-arrestin activation
Agonist-induced GPCR phosphorylation is a key determinant for the binding and activation
of β-arrestins (βarrs). However, it is not entirely clear how different GPCRs harboring …
of β-arrestins (βarrs). However, it is not entirely clear how different GPCRs harboring …
β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells
Abstract β-arrestins mediate regulatory processes for over 800 different G protein-coupled
receptors (GPCRs) by adopting specific conformations that result from the geometry of the …
receptors (GPCRs) by adopting specific conformations that result from the geometry of the …
Plasma membrane preassociation drives β-arrestin coupling to receptors and activation
Summary β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and
desensitization. Despite recent structural advances, the mechanisms that govern receptor-β …
desensitization. Despite recent structural advances, the mechanisms that govern receptor-β …
G protein–coupled receptor interactions with arrestins and GPCR kinases: The unresolved issue of signal bias
Q Chen, JJG Tesmer - Journal of Biological Chemistry, 2022 - ASBMB
G protein–coupled receptor (GPCR) kinases (GRKs) and arrestins interact with agonist-
bound GPCRs to promote receptor desensitization and downregulation. They also trigger …
bound GPCRs to promote receptor desensitization and downregulation. They also trigger …
Receptor-arrestin interactions: the GPCR perspective
M Seyedabadi, M Gharghabi, EV Gurevich… - Biomolecules, 2021 - mdpi.com
Arrestins are a small family of four proteins in most vertebrates that bind hundreds of
different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three …
different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three …
A key GPCR phosphorylation motif discovered in arrestin2⋅ CCR5 phosphopeptide complexes
The two non-visual arrestins, arrestin2 and arrestin3, bind hundreds of GPCRs with different
phosphorylation patterns, leading to distinct functional outcomes. Structural information on …
phosphorylation patterns, leading to distinct functional outcomes. Structural information on …
Structure, function and drug discovery of GPCR signaling
L Cheng, F Xia, Z Li, C Shen, Z Yang, H Hou… - Molecular …, 2023 - Springer
G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …
array of physiological processes and responses, such as sensory perception (eg, vision …