Cyclohepta[b]pyran: an important scaffold in biologically active natural products

M Haji, M Hosseinzadeh - Medicinal Chemistry Research, 2022 - Springer
Heterocycle-fused cycloheptanoid derivatives are one of the specific natural product
scaffolds with a broad range of biological and pharmaceutical activities. Seven-membered …

Synthesis of novel pyrazole derivatives using organophosphorus, stibine, and arsine reagents and their antitumor activities

NF El-Sayed, EF Ewies, M El-Hussieny… - … für Naturforschung B, 2016 - degruyter.com
Abstract The reactions of 5-azido-3-methyl-1-phenyl-1 H-pyrazole-4-carbaldehyde
(azidopyrazole) with several classes of organophosphorus reagents: phosphonium ylides …

Linking mutagenic activity to micropollutant concentrations in wastewater samples by partial least square regression and subsequent identification of variables

C Hug, M Sievers, R Ottermanns, H Hollert, W Brack… - Chemosphere, 2015 - Elsevier
We deployed multivariate regression to identify compounds co-varying with the mutagenic
activity of complex environmental samples. Wastewater treatment plant (WWTP) effluents …

A green protocol for one pot synthesis of benzosuberone tethered thiadiazolopyrimidine-6-carboxylates using PEG-400 as potent anti-proliferative agents

S Kasaboina, R Bollu, PM Gomedhika, V Ramineni… - Tetrahedron …, 2018 - Elsevier
A new concise and facile method was explored to synthesize a collection of new
benzosuberone based thiadiazolo [3, 2-a] pyrimidine-6-carboxylates using polyethylene …

Synthetic Approaches and Pharmacological Attributes of Benzosuberone Skeleton

SNA Bukhari - Mini Reviews in Medicinal Chemistry, 2023 - ingentaconnect.com
Background: Benzocycloheptanone is the main structural feature of numerous famous
natural pharmacophores such as Colchicine and Theaflavins. It has gained popularity in the …

Synthesis, characterization, and antitumor evaluation of 4-aminoximidofurazan derivatives

EF Ewies, M El-Hussieny, NF El-Sayed… - … , Sulfur, and Silicon …, 2016 - Taylor & Francis
ABSTRACT Reactions of 3-amino-4-aminoximidofurazan (AAOF) with Wittig–Horner
reagents, trialkylphosphites, trisdialkylaminophosphines as well as the thiating Lawesson …

Synthesis of novel 1, 2-diphenylpyrrole derivatives using organophosphorus reagents and their antitumour activities

EF Ewies, NF Elsayed, LS Boulos… - Journal of Chemical …, 2014 - journals.sagepub.com
The reactions are reported of 4-(furan-3-ylcarbonyl)-1, 5-diphenylpyrrolidine-2, 3-dione with
six classes of organophosphorus reagents: carboalkoxymethylene triphenylphosphoranes …

Reaction of 1,1-Bis(Diphenylphosphino)Methane with O-Quinones and Naphtho[2,1-B]Furan-1,2-Dione. Novel Synthesis of Bis(Diphenylphosphoryl) Derivatives and …

LS Boulos, EF Ewies, NM Ibrahim… - Phosphorus, Sulfur, and …, 2014 - Taylor & Francis
Abstract The reaction of 1, 1-bis (diphenylphosphino) methane with substituted o-quinones
afforded the novel 6-[bis (diphenylphosphoryl) methyl]-and 6-bis (diphenyl phosphoryl) …

Efficient Synthesis and Antimicrobial Evaluation of New Organophosphorus Dioxaspirodecanone Derivatives

HR El-Shanawany, SS Maigali… - Egyptian Journal of …, 2022 - journals.ekb.eg
Claisen-Schmidt condensation reaction of 1, 4-cyclohexanedione monoethyleneketal (1)
with p-methoxybenzaldehyde, under base catalyzed conditions, has afforded 7, 9 bis (4 …

[PDF][PDF] In vitro anti-proliferative activity of newly synthesized compounds of substituted-(3-phenyl-1, 2, 4-oxadiazol-5yl)-methyl-9-chloro-2, 3-dimethyl-6, 7-dihydro-5H …

PM Gomedhika, NJP Subhashini - 2022 - academia.edu
With the discovery of Colchicine [1, 2](I), the anticancer effect of benzosuberone has been
raised since 1984. In drug discovery program Benzosuberone, which contain the core …