The ventilatory control system is highly vulnerable to exogenous administered opioid
analgesics. Particularly respiratory depression is a potentially lethal complication that may …

Understanding the neurobiological mechanisms of post-traumatic stress disorder (PTSD) is
of vital importance for developing biomarkers and more effective pharmacotherapy for this …

Major depressive disorder (MDD) is a common and severe disease characterized by mood
changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the …

Major depression is a highly prevalent severe mood disorder that is treated with
antidepressants. The molecular targets of antidepressants require definition. We …

An important role of modern forensic and clinical toxicologists is to monitor the adverse
events of novel psychoactive substances (NPS). Following a prior review from 2013 to 2016 …

The rate-limiting enzyme in serotonin synthesis is tryptophan hydroxylase (TPH). There are
two independent serotonin systems in the body characterized by two isoforms of TPH, TPH1 …

Major depressive disorder (MDD) is a very common, severe disease with a lifetime
prevalence of~ 10%. The pathogenesis of MDD is unknown and, unfortunately, therapy is …

Major depressive disorder (MDD) is a severe disease of unknown pathogenesis that will
affect∼ 10% of people during their lifetime. Therapy for MDD requires prolonged treatment …

Despite significant research efforts aimed at understanding the neurobiological
underpinnings of mood (depression, bipolar disorder) and psychotic disorders, the …

Major depressive disorder (MDD) is a common and severe mental disorder that is usually
recurrent and has a high risk of suicide. This disorder manifests not only with psychological …