The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …

Background Synapse damage and loss are fundamental to the pathophysiology of
Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is to …

A major feature of Alzheimer's disease (AD) pathology is the plaque composed of
aggregated amyloid-β (Aβ) peptide. Although these plaques may have harmful properties …

Amyloid-β (Aβ) is the predominant pathologic protein in Alzheimer's disease (AD). The
production and deposition of Aβ are important factors affecting AD progression and …

Alzheimer's disease (AD) is the most prevalent form of dementia which affects people older
than 60 years of age. In AD, the dysregulation of the amyloid-beta (Aβ) level leads to the …

Alzheimer's disease (AD) is the most common form of dementia in the elderly, and affects
millions of people worldwide. As the number of AD cases continues to increase in both …

β‐amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying
Alzheimer's disease (AD), although there is presently lively debate regarding the relative …

Alzheimer's disease begins about two decades before the onset of symptoms or neuron
death, and is believed to be caused by pathogenic amyloid-β aggregates that initiate a …

Alzheimer's disease (AD) and type 2 diabetes appear to share similar pathogenic
mechanisms. dsRNA-dependent protein kinase (PKR) underlies peripheral insulin …

The oligomer cascade hypothesis, which states that oligomers are the initiating pathologic
agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis …