Consensus summary statement of the international multidisciplinary consensus conference on multimodality monitoring in neurocritical care: a statement for …

P Le Roux, DK Menon, G Citerio, P Vespa, MK Bader… - Neurocritical care, 2014 - Springer
Neurocritical care depends, in part, on careful patient monitoring but as yet there are little
data on what processes are the most important to monitor, how these should be monitored …

Microglia-mediated inflammation and neurodegenerative disease

L Xu, D He, Y Bai - Molecular Neurobiology, 2016 - Springer
Microglia are the main effectors in the inflammatory process of the central nervous system.
As the first line of defense, microglia play an important role in the inflammatory reaction …

Pathophysiology of traumatic brain injury

C Werner, K Engelhard - British journal of anaesthesia, 2007 - academic.oup.com
The knowledge of the pathophysiology after traumatic head injury is necessary for adequate
and patient-oriented treatment. As the primary insult, which represents the direct mechanical …

The molecular pathophysiology of concussive brain injury

G Barkhoudarian, DA Hovda… - Clinics in sports …, 2011 - sportsmed.theclinics.com
Concussion (or mild traumatic brain injury, mTBI) is a biomechanically induced neurological
injury, resulting in an alteration of mental status, such as confusion or amnesia, which may …

The molecular pathophysiology of concussive brain injury–an update

G Barkhoudarian, DA Hovda… - Physical Medicine and …, 2016 - pmr.theclinics.com
Concussion (mild traumatic brain injury [TBI]), particularly with organized sports, has come to
the forefront of popular culture. Affecting about 1.6 million to 3.8 million athletes a year, its …

A review of the effectiveness of neuroimaging modalities for the detection of traumatic brain injury

F Amyot, DB Arciniegas, MP Brazaitis… - Journal of …, 2015 - liebertpub.com
The incidence of traumatic brain injury (TBI) in the United States was 3.5 million cases in
2009, according to the Centers for Disease Control and Prevention. It is a contributing factor …

Monitoring the injured brain: ICP and CBF

LA Steiner, PJD Andrews - BJA: British Journal of Anaesthesia, 2006 - academic.oup.com
Raised intracranial pressure (ICP) and low cerebral blood flow (CBF) are associated with
ischaemia and poor outcome after brain injury. Therefore, many management protocols …

Diffusion limited oxygen delivery following head injury

DK Menon, JP Coles, AK Gupta, TD Fryer… - Critical care …, 2004 - journals.lww.com
Objective: To use a range of techniques to explore diffusion limitation as a mechanism of
cellular hypoxia in the setting of head injury. Design: A prospective interventional study …

Multi-disciplinary management of athletes with post-concussion syndrome: an evolving pathophysiological approach

MJ Ellis, J Leddy, B Willer - Frontiers in neurology, 2016 - frontiersin.org
Historically, patients with sports-related concussion (SRC) have been managed in a uniform
fashion consisting mostly of prescribed physical and cognitive rest with the expectation that …

Brain energy metabolism: A roadmap for future research

CD Rae, JA Baur, K Borges, G Dienel… - Journal of …, 2024 - Wiley Online Library
Although we have learned much about how the brain fuels its functions over the last
decades, there remains much still to discover in an organ that is so complex. This article lays …