We introduce a non-myopic, covariate-adjusted response adaptive (CARA) allocation
design for multi-armed clinical trials. The allocation scheme is a computationally tractable …

Response-adaptive designs have recently attracted more and more attention in the literature
because of its advantages in efficiency and medical ethics. To develop personalized …

This book aids in identifying when to apply adaptive randomization designs in practice.
Featuring contributions from statisticians, clinical trialists, and subject-matter experts in …

<? show [AQ ID= GQ2 POS=-24pt]?><? show [AQ ID= GQ5 POS= 12pt]?> Covariate-
adjusted response adaptive (CARA) designs are effective in increasing the expected …

Results obtained from reliably designed randomized experiments are often considered to be
evidence of the highest grade for assessing the effectiveness of biomedical or behavioral …

Tie-breaker designs trade off a measure of statistical efficiency against a short-term gain
from preferentially assigning a binary treatment to subjects with higher values of a running …

Covariate-adjusted response-adaptive designs use the available responses to skew
treatment allocation in a clinical trial, in favour of the treatment, found at an interim stage of …

Study designs incorporate interim analyses to allow for modifications to the trial design.
These analyses may aid decisions regarding sample size, futility, and safety. Furthermore …

This chapter is devoted to the study of a so-called group-sequential CARA randomized
controlled trial (RCT), with a particular focus on incorporating more flexible (ie, data …

In clinical trials, comparisons of treatments with ordinal responses are frequently conducted
using the proportional odds model. However, the use of this model necessitates the …