Molecular docking studies of tyrosine kinase inhibitors: Exemplified protocol to advance pharmaceutical education in medicinal chemistry

IH Gani, Z Al-Obaidi - Pharmacy Education, 2022 - pharmacyeducation.fip.org
Background: One of the essential goals of pharmacy education is to extend professional
learning to pharmacists, pharmacy students and educators. Medicinal chemistry is a major …

MgO NPs catalyzed the synthesis of novel pyridin-3-yl-pyrimidin-2-yl-aminophenyl-amide derivatives and evaluation of pharmacokinetic profiles and biological activity

IH Gani, Z Al-Obaidi - Frontiers in Materials, 2023 - frontiersin.org
In this study, novel pyridin-3-yl-pyrimidin-2-yl-aminophenyl-amide derivatives using two
methods, namely, using trimethylamine as a classical method and using magnesium oxide …

Design, molecular docking, synthesis and evaluation of new isatin derivatives bearing pyridine moiety as potential tyrosine kinase inhibitors

NW Ibrahim, M Mahdi, AMR Raauf - Egyptian Journal of Chemistry, 2022 - journals.ekb.eg
A series of new 1-(3-imino-2-oxoindolin-5-yl)-3-phenylurea derivatives were synthesized
starting from 5-aminoisatin; as a part of our program to compose multicomponent hybrid …

Synthesis and anti-breast cancer activity evaluation of the designed chlorobenzothiophene derivatives: Promising estrogen receptor alpha inhibitors

MF Al-Owaidi, MF Mahdi - Egyptian Journal of Chemistry, 2023 - ejchem.journals.ekb.eg
Breast cancer is the second leading cause of death in women. Fulvestrant and tamoxifen
(TAM) are the most extensively used medications to treat breast cancer. However, these …

Design, Molecular Docking Studies, Synthesis and Characterization of some New 4, 5-dihydro-1H-Pyrazole-1-yl acetate Derivatives as Cyclooxygenase Inhibitors

SZ Abdul-Majeed, MF Mahdi… - Research Journal of …, 2022 - indianjournals.com
To develop novel anti-inflammatory scaffolds, a new series of 4, 5-dihydro-1H-pyrazole-1-yl
acetate derivatives synthesized through different chemical reactions and validated …

[PDF][PDF] Synthesis, characterization, and pharmacological evaluation of new imatinib analogues as antiproliferative agents

IH Gani, Z Al-Obaidi - researchgate.net
Cancer is the second cause of death after the cardiovascular disease. There are many target
receptors for a drug that acts as an anticancer. One of these targets is the tyrosine kinase …