Role of urotensin II in health and disease

B Ross, K McKendy, A Giaid - American Journal of …, 2010 - journals.physiology.org
Urotensin II (UII) is an 11 amino acid cyclic peptide originally isolated from the goby fish. The
amino acid sequence of UII is exceptionally conserved across most vertebrate taxa, sharing …

International union of basic and clinical pharmacology. XCII. Urotensin II, urotensin II–related peptide, and their receptor: From structure to function

H Vaudry, J Leprince, D Chatenet, A Fournier… - Pharmacological …, 2015 - Elsevier
Urotensin II (UII) is a cyclic neuropeptide that was first isolated from the urophysis of teleost
fish on the basis of its ability to contract the hindgut. Subsequently, UII was characterized in …

[HTML][HTML] Myocarditis in COVID-19: a focus on the pediatric population

B Sleem, R Zareef, F Bitar, M Arabi - American Journal of …, 2023 - ncbi.nlm.nih.gov
The emergence of the novel SARS-CoV-2 virus in late 2019 introduced new, unpreceded
global challenges. Complications arising from COVID-19 widely range from mild to severe …

Human urotensin II as a link between hypertension and coronary artery disease

T Watanabe, T Kanome, A Miyazaki, T Katagiri - Hypertension research, 2006 - nature.com
Hypertension is a well-known risk factor for atherosclerosis, but the molecular mechanisms
that link elevated blood pressure to the progression of atherosclerosis remain unclear …

[HTML][HTML] Natural and synthetic peptides in the cardiovascular diseases: An update on diagnostic and therapeutic potentials

P Grieco, I Gomez-Monterrey - Archives of biochemistry and biophysics, 2019 - Elsevier
Several peptides play an important role in physiological and pathological conditions into the
cardiovascular system. In addition to well-known vasoactive agents such as angiotensin II …

Urotensin-II, oxidative stress, and inflammation increase in hypertensive and resistant hypertensive patients

EM Guler, M Gokce, A Bacaksiz… - Clinical and Experimental …, 2021 - Taylor & Francis
Objective: Hypertension is a multi-factorial process prevalent in developed as well as in
developing countries. Urotensin-II, different antioxidants, free radicals, and inflammatory …

Human urotensin II promotes hypertension and atherosclerotic cardiovascular diseases

T Watanabe, S Arita, Y Shiraishi… - Current medicinal …, 2009 - ingentaconnect.com
Human urotensin II (U-II), the most potent vasoconstrictor undecapeptide identified to date,
and its receptor (UT) are involved in the pathogenesis of systemic and pulmonary …

The role of urotensin II in the metabolic syndrome

KL Ong, LYF Wong, BMY Cheung - Peptides, 2008 - Elsevier
Urotensin II is a potent vasoconstrictive peptide that mediates both endothelium-
independent vasoconstriction and endothelium-dependent vasodilatation. Its plasma level …

Association between human urotensin II and essential hypertension—a 1: 1 matched case-control study

H Peng, M Zhang, X Cai, J Olofindayo, A Tan… - PLoS One, 2013 - journals.plos.org
Objective We aimed to evaluate the controversial association between human urotensin II
and essential hypertension in untreated hypertensive cases and normotensive controls …

Urotensin-II and cardiovascular diseases

N Bousette, A Giaid - Current hypertension reports, 2006 - Springer
Abstract Urotensin-II (U-II) is a vasoactive factor with pleiotropic effects. U-II exerts its activity
by binding to a G-protein-coupled receptor termed UT. U-II and its receptor are highly …