The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …

The discovery of cisplatin's antitumor activity in 1969 prompted the search for novel metal-
containing complexes as potential anticancer drugs. Among these novel complexes, metal N …

Metal complexes with N-heterocyclic carbene (NHC) ligands are widely used in chemistry
due to their catalytic properties and applied for olefin metathesis among other reactions. The …

This review provides an introduction into the fascinating area of organometallic anticancer
compounds. Although the subject dates back many years, it has witnessed considerable …

Ofele and Wanzlick reported the synthesis of the first N-heterocyclic carbene (NHC)-metal
complexes in 1968. 1, 2 The isolation of the first free carbene by Arduengo in 1991 set the …

An N-heterocyclic carbene (NHC) contains a carbene carbon incorporated in a nitrogen-
containing heterocycle, presumably reactive and difficult to isolate. 1 The first isolation of …

Metal complexes have shown interesting preclinical and clinical results as antitumor drugs
and platinum compounds are well established in current cancer chemotherapy. However …

Gold compounds are a class of metallodrugs with great potential for cancer treatment.
During the last two decades, a large variety of gold (I) and gold (III) compounds are reported …

Gold (I) complexes such as auranofin have been used for decades to treat symptoms of
rheumatoid arthritis and have also demonstrated a considerable potential as new anticancer …

Within the research field of antitumor metal-based agents alternative to platinum drugs, gold
(I/III) coordination complexes have always been in the forefront due mainly to the familiarity …