Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Human-based modelling and simulations are becoming ubiquitous in biomedical science
due to their ability to augment experimental and clinical investigations. Cardiac …

Drug-induced torsades de pointes (TdP) arrhythmia is a major safety concern in the process
of drug design and development. The incidence of TdP tends to be low, so early pre-clinical …

The fine tuning of biological electrical signaling is mediated by variations in the rates of
opening and closing of gates that control ion flux through different ion channels. Human …

The congenital short QT syndrome (SQTS) is a rare condition characterized by abbreviated
rate-corrected QT (QTc) intervals on the electrocardiogram and by increased susceptibility to …

The human voltage-sensitive K+ channel hERG plays a fundamental role in cardiac action
potential repolarization, effectively controlling the QT interval of the electrocardiogram …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

Objectives: This study sought to evaluate mutations in genes encoding the slow component
of the cardiac delayed rectifier K+ current (I Ks) channel in familial atrial fibrillation (AF) …

Drug block of the human ether-à-go-go-related gene K+ channel (hERG) is the most
common cause of acquired long QT syndrome, a disorder of cardiac repolarization that may …