Synthetic alternatives to Matrigel

EA Aisenbrey, WL Murphy - Nature Reviews Materials, 2020 - nature.com
Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

Materials as stem cell regulators

WL Murphy, TC McDevitt, AJ Engler - Nature materials, 2014 - nature.com
The stem cell/material interface is a complex, dynamic microenvironment in which the cell
and the material cooperatively dictate one another's fate: the cell by remodelling its …

Nanotopography influences adhesion, spreading, and self-renewal of human embryonic stem cells

W Chen, LG Villa-Diaz, Y Sun, S Weng, JK Kim… - ACS …, 2012 - ACS Publications
Human embryonic stem cells (hESCs) have great potentials for future cell-based
therapeutics. However, their mechanosensitivity to biophysical signals from the cellular …

Concise review: the evolution of human pluripotent stem cell culture: from feeder cells to synthetic coatings

LG Villa-Diaz, AM Ross, J Lahann, PH Krebsbach - Stem cells, 2013 - academic.oup.com
Current practices to maintain human pluripotent stem cells (hPSCs), which include induced
pluripotent stem cells and embryonic stem cells, in an undifferentiated state typically depend …

Derivation of mesenchymal stem cells from human induced pluripotent stem cells cultured on synthetic substrates

LG Villa-Diaz, SE Brown, Y Liu, AM Ross, J Lahann… - Stem …, 2012 - academic.oup.com
Human-induced pluripotent stem cells (hiPSCs) may represent an ideal cell source for
research and applications in regenerative medicine. However, standard culture conditions …

A composite chitosan-gelatin bi-layered, biomimetic macroporous scaffold for blood vessel tissue engineering

RV Badhe, D Bijukumar, DR Chejara, M Mabrouk… - Carbohydrate …, 2017 - Elsevier
A composite chitosan-gelatin macroporous hydrogel-based scaffold with bi-layered tubular
architecture was engineered by solvent casting-co-particulate leaching. The scaffold …

Human embryonic stem cell cultivation: historical perspective and evolution of xeno-free culture systems

N Desai, P Rambhia, A Gishto - Reproductive Biology and Endocrinology, 2015 - Springer
Human embryonic stem cells (hESC) have emerged as attractive candidates for cell-based
therapies that are capable of restoring lost cell and tissue function. These unique cells are …

Polymer coatings for biomedical applications: a review

JR Smith, DA Lamprou - Transactions of the IMF, 2014 - Taylor & Francis
This review surveys some of the recent literature concerning the use of polymer coatings for
a variety of biomedical applications. These have been grouped into six broad categories …

Mechanics regulates fate decisions of human embryonic stem cells

Y Sun, LG Villa-Diaz, RHW Lam, W Chen… - PloS one, 2012 - journals.plos.org
Research on human embryonic stem cells (hESCs) has attracted much attention given their
great potential for tissue regenerative therapy and fundamental developmental biology …

Production of mesenchymal stem cells through stem cell reprogramming

A Abdal Dayem, SB Lee, K Kim, KM Lim… - International journal of …, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) possess a broad spectrum of therapeutic applications and
have been used in clinical trials. MSCs are mainly retrieved from adult or fetal tissues …