The artificial pancreas (AP), known as closed-loop control of blood glucose in diabetes, is a
system combining a glucose sensor, a control algorithm, and an insulin infusion device. AP …

Medical cyber-physical systems (MCPS) are life-critical, context-aware, networked systems
of medical devices. These systems are increasingly used in hospitals to provide high-quality …

Arguably, a minimally invasive system using subcutaneous (sc) continuous glucose
monitoring (CGM) and sc insulin delivery via insulin pump would be a most feasible step to …

The control of diabetes is an interdisciplinary endeavor, which includes a significant
biomedical engineering component, with traditions of success beginning in the early 1960s …

Automated closed-loop insulin delivery, also referred to as the'artificial pancreas', has been
an important but elusive goal of diabetes treatment for many decades. Research milestones …

OBJECTIVE Current state-of-the-art artificial pancreas systems are either based on
traditional linear control theory or rely on mathematical models of glucose-insulin dynamics …

Background Canagliflozin is a sodium glucose co-transporter (SGLT) 2 inhibitor in clinical
development for the treatment of type 2 diabetes mellitus (T2DM). Methods 14C-alpha …

OBJECTIVE To evaluate two widely used control algorithms for an artificial pancreas (AP)
under nonideal but comparable clinical conditions. RESEARCH DESIGN AND METHODS …

Despite the continuous efforts devoted to AP development in the last decades, an artificial
pancreas (AP) system is not yet available on the market. One of the major issues involves …

Pursuit of a closed-loop artificial pancreas that automatically controls the blood glucose of
individuals with type 1 diabetes has intensified during the past 6years. Here we discuss the …