Lung cancer remains the leading cause of cancer mortality in men and women in the US
and worldwide. About 90% of lung cancer cases are caused by smoking and the use of …

Advances in chemotherapy and targeted therapies have improved survival in cancer
patients with an increase of the incidence of newly diagnosed brain metastases (BMs) …

Brain metastases are an important cause of morbidity and mortality, afflicting nearly 170,000
Americans annually. The prognosis for these patients is poor, with median survival times …

Brain metastases occur in 20–40% of patients with cancer and their frequency has
increased over time. Lung, breast and skin (melanoma) are the commonest sources of brain …

The incidence of brain metastases is increasing as cancer therapies improve and patients
live longer, providing new challenges to the multidisciplinary teams that care for these …

Purpose: To systematically review the evidence for the use of stereotactic radiosurgery in
adult patients with brain metastases. Methods: Key clinical questions to be addressed in this …

Brain metastases are the most common type of brain tumor in adults and are an increasingly
important cause of morbidity and mortality in cancer patients. In recent years, important …

Background: Treatment options for patients with recurrent brain metastases are extremely
limited. This study was designed to determine the safety and efficacy of temozolomide in the …

Purpose To determine whether efaproxiral, an allosteric modifier of hemoglobin, improves
survival in patients with brain metastases when used as an adjunct to whole-brain radiation …

Brain metastases are the most common neurological complication of systemic cancer and
carry a very poor prognosis. The management of patients with brain metastases has become …