Curing HIV: seeking to target and clear persistent infection
Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …
Exhausted NK cells and cytokine storms in COVID-19: Whether NK cell therapy could be a therapeutic choice
M Ghasemzadeh, A Ghasemzadeh, E Hosseini - Human immunology, 2022 - Elsevier
The global outbreak of coronavirus-2019 (COVID-19) still claims more lives daily around the
world due to the lack of a definitive treatment and the rapid tendency of virus to mutate …
world due to the lack of a definitive treatment and the rapid tendency of virus to mutate …
Interleukin-2 therapy of cancer-clinical perspectives
J Majidpoor, K Mortezaee - International immunopharmacology, 2021 - Elsevier
Abstract Interleukin (IL)-2 is a pleiotropic cytokine that displays opposing activities on
immune system acting either in favor of or against cancer progression. Advanced/metastatic …
immune system acting either in favor of or against cancer progression. Advanced/metastatic …
Targeting natural killer cells for improved immunity and control of the adaptive immune response
Natural killer (NK) cells are critical for targeting and killing tumor, virus-infected and stressed
cells as a member of the innate immune system. Recently, NK cells have also emerged as …
cells as a member of the innate immune system. Recently, NK cells have also emerged as …
IL-15 and N-803 for HIV cure approaches
JN Howard, A Bosque - Viruses, 2023 - mdpi.com
In spite of the advances in antiretroviral therapy to treat HIV infection, the presence of a
latent reservoir of HIV-infected cells represents the largest barrier towards finding a cure …
latent reservoir of HIV-infected cells represents the largest barrier towards finding a cure …
CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies
ABSTRACT HIV-1 envelope glycoprotein (Env) conformation substantially impacts antibody-
dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion …
dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion …
Self-assembling peptide nanofiber HIV vaccine elicits robust vaccine-induced antibody functions and modulates Fc glycosylation
To develop vaccines for certain key global pathogens such as HIV, it is crucial to elicit both
neutralizing and non-neutralizing Fc-mediated effector antibody functions. Clinical evidence …
neutralizing and non-neutralizing Fc-mediated effector antibody functions. Clinical evidence …
Safety and immunogenicity of a polyvalent DNA–protein HIV vaccine with matched Env immunogens delivered as a prime–boost regimen or coadministered in HIV …
I Frank, SS Li, N Grunenberg, ET Overton… - The Lancet …, 2024 - thelancet.com
Background An effective HIV vaccine will most likely need to have potent immunogenicity
and broad cross-subtype coverage. The aim of the HIV Vaccine Trials Network (HVTN) 124 …
and broad cross-subtype coverage. The aim of the HIV Vaccine Trials Network (HVTN) 124 …
Safety and immune responses after a 12-month booster in healthy HIV-uninfected adults in HVTN 100 in South Africa: A randomized double-blind placebo-controlled …
Background HVTN 100 evaluated the safety and immunogenicity of an HIV subtype C pox-
protein vaccine regimen, investigating a 12-month booster to extend vaccine-induced …
protein vaccine regimen, investigating a 12-month booster to extend vaccine-induced …
Immunopotentiation effects of apigenin on NK cell proliferation and killing pancreatic cancer cells
YB Feng, L Chen, FX Chen, Y Yang… - International …, 2023 - journals.sagepub.com
Apigenin is a kind of flavonoid with many beneficial biological effects. It not only has direct
cytotoxicity to tumor cells, but also can boost the antitumor effect of immune cells by …
cytotoxicity to tumor cells, but also can boost the antitumor effect of immune cells by …