Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied
female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated …

The L1 cell adhesion molecule (L1CAM) plays a major role in the development of the
nervous system and in the malignancy of human tumors. In terms of biological function …

Members of the nuclear factor-κB (NF-κB) family of transcriptional regulators are central
mediators of the cellular inflammatory response. Although constitutive NF-κB signalling is …

Background L1 cell adhesion molecule (L1CAM) expression has been implicated as risk
factor for disease recurrence in endometrial cancer (EC), most likely due to its role in …

Patients with melanoma receiving drugs targeting BRAFV600E and mitogen-activated
protein (MAP) kinase kinases 1 and 2 (MEK1/2) invariably develop resistance and face …

Malignant tumors of the central nervous system (CNS) are among cancers with the poorest
prognosis, indicated by their association with tumors of high-level morbidity and mortality …

Pancreatic stellate cells (PSCs) secrete high levels of transforming growth factor-β1 (TGF-
β1) that contributes to the development of pancreatic ductal adenocarcinoma (PDAC). TGF …

Background Cancer stem cells (CSC) have been implicated in tumor progression. In ovarian
carcinoma (OC), CSC drive tumor formation, dissemination and recurrence, as well as drug …

Ezrin is the cytoskeletal organizer and functions in the modulation of membrane–
cytoskeleton interaction, maintenance of cell shape and structure, and regulation of cell–cell …

L1CAM is a cell adhesion molecule of the immunoglobulin superfamily which was originally
discovered as a major player in the development of the nervous system. L1CAM was …