Combined with TCR stimuli, extracellular cytokine signals initiate the differentiation of naive
CD 4+ T cells into specialized effector T‐helper (Th) and regulatory T (Treg) cell subsets …

The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of
serine/threonine kinases that regulates numerous signaling networks that promote cell …

Uveitis is a severe autoimmune disease, and a common cause of blindness; however, its
individual cellular dynamics and pathogenic mechanism remain poorly understood. Herein …

The serine/threonine-specific Moloney murine leukemia virus (PIM) kinase family (ie, PIM1,
PIM2, and PIM3) has been extensively studied in tumorigenesis. PIM kinases are …

PIM kinases are oncogenic serine/threonine kinases, the expression and activities of which
are tightly regulated in normal tissues, but upregulated in many types of human …

The Pim (proviral integration site for Moloney murine leukemia virus) proteins compose a
serine threonine kinase family whose members regulate cell proliferation, migration and cell …

Pim kinase, which has three isozymes (Pim-1, Pim-2 and Pim-3), is a serine/threonine
kinase abnormally expressed in many cancers. High Pim kinase expression has been …

Hepatocellular carcinoma (HCC) is characteristically one of the most rapidly proliferating
tumors which outgrows functional blood supply and results in regional oxygen deprivation …

Introduction: STAT4, which acts as the major signaling transducing STATs in response to IL-
12, is a central mediator in generating inflammation during protective immune responses …

Cancer is one of the leading causes of death worldwide, resulting in the deaths of millions of
individuals. Owing to the development of drug resistance to conventional therapies …