CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances

KM Maalej, M Merhi, VP Inchakalody, S Mestiri… - Molecular Cancer, 2023 - Springer
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of …

CAR-T therapies in solid tumors: opportunities and challenges

G Guzman, MR Reed, K Bielamowicz, B Koss… - Current Oncology …, 2023 - Springer
Abstract Purpose of Review This review will discuss the challenges facing chimeric antigen
receptor (CAR)-T cell application for solid tumors and opportunities to overcome these …

The emergence of cancer sono-immunotherapy

Y Yang, Y Cheng, L Cheng - Trends in Immunology, 2024 - cell.com
Owing to its remarkable ease of use, ultrasound has recently been explored for stimulating
or amplifying immune responses during cancer therapy, termed 'sono-immunotherapy' …

CAR T cell therapy in glioblastoma: overcoming challenges related to antigen expression

AS Luksik, E Yazigi, P Shah, CM Jackson - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma is the most common brain cancer, and prognosis remains
dismal. Continued efforts to find better treatments have shown the promise of …

The immunosuppressive microenvironment and immunotherapy in human glioblastoma

X Zhang, L Zhao, H Zhang, Y Zhang, H Ju… - Frontiers in …, 2022 - frontiersin.org
Glioblastoma multiforme (GBM) is the most malignant intracranial tumor in adults,
characterized by extensive infiltrative growth, high vascularization, and resistance to multiple …

Adeno-associated virus delivered CXCL9 sensitizes glioblastoma to anti-PD-1 immune checkpoint blockade

CA von Roemeling, JA Patel, SL Carpenter… - Nature …, 2024 - nature.com
There are numerous mechanisms by which glioblastoma cells evade immunological
detection, underscoring the need for strategic combinatorial treatments to achieve …

Advancements in CAR-NK therapy: lessons to be learned from CAR-T therapy

MK Kilgour, DJ Bastin, SH Lee, M Ardolino… - Frontiers in …, 2023 - frontiersin.org
Advancements in chimeric antigen receptor engineered T-cell (CAR-T) therapy have
revolutionized treatment for several cancer types over the past decade. Despite this success …

Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics

R Thapa, M Afzal, A Goyal, G Gupta, AA Bhat… - Life sciences, 2024 - Elsevier
Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a
discouragingly low survival rate and few effective treatments. An important function of the …

Hypoxia within the glioblastoma tumor microenvironment: a master saboteur of novel treatments

L Feldman - Frontiers in Immunology, 2024 - frontiersin.org
Glioblastoma (GBM) tumors are the most aggressive primary brain tumors in adults that,
despite maximum treatment, carry a dismal prognosis. GBM tumors exhibit tissue hypoxia …

Chimeric antigen receptor T cells targeting cell surface GRP78 efficiently kill glioblastoma and cancer stem cells

S Wang, W Wei, Y Yuan, B Sun, D Yang, N Liu… - Journal of Translational …, 2023 - Springer
Background Glioblastoma (GBM) is recognized as among the most aggressive forms of
brain tumor. Patients typically present with a five-year survival rate of less than 6% with …