Six GATA transcription factors have been identified in vertebrates, each of which contains a
highly conserved DNA binding domain consisting of two zinc fingers of the motif Cys-X2-Cys …

During the past decade, emerging evidence has accumulated of different nuclear
transcription factors in regulation of cardiac development and growth as well as in cardiac …

The zinc finger transcription factor GATA4 has been implicated in heart development based
on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the …

Previous studies have suggested that the GATA4 transcription factor plays an important role
in regulating mammalian cardiac development. In the studies described in this report we …

GATA6 belongs to a family of zinc finger transcription factors that play important roles in
transducing nuclear events that regulate cellular differentiation and embryonic …

The tissue‐restricted GATA‐4 transcription factor and Nkx2‐5 homeodomain protein are two
early markers of precardiac cells. Both are essential for heart formation, but neither can …

Little is known about the molecular mechanisms that govern heart specification in
vertebrates. Here we demonstrate that bone morphogenetic protein (BMP) signaling plays a …

The GATA-binding transcription factors comprise a protein family whose members contain
either one or two highly conserved zinc finger DNA-binding domains. Members of this group …

Heart formation requires complex interactions among cells from multiple embryonic origins.
Recent studies have begun to reveal the genetic pathways that control cardiac …

Troponin is the regulatory complex of the myofibrillar thin filament that plays a critical role in
regulating excitation-contraction coupling in the heart. Troponin is composed of three distinct …