Protein design: From the aspect of water solubility and stability

R Qing, S Hao, E Smorodina, D Jin, A Zalevsky… - Chemical …, 2022 - ACS Publications
Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Bioactive potential of natural biomaterials: Identification, retention and assessment of biological properties

K Joyce, GT Fabra, Y Bozkurt, A Pandit - Signal transduction and …, 2021 - nature.com
Biomaterials have had an increasingly important role in recent decades, in biomedical
device design and the development of tissue engineering solutions for cell delivery, drug …

Evolutionary constraint and innovation across hundreds of placental mammals

MJ Christmas, IM Kaplow, DP Genereux, MX Dong… - Science, 2023 - science.org
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Connective tissue growth factor: from molecular understandings to drug discovery

Z Chen, N Zhang, HY Chu, Y Yu, ZK Zhang… - Frontiers in cell and …, 2020 - frontiersin.org
Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved
in different biological processes, such as cell proliferation, angiogenesis, and wound …

[HTML][HTML] Effect of L-cysteine and L-ascorbic acid addition on properties of meat analogues

ST Dinani, JP van der Harst, R Boom… - Food Hydrocolloids, 2023 - Elsevier
Currently, studies are underway to use pea protein isolate (PPI) for the production of meat
analogues because it is considered as a more sustainable alternative to soy. The potential …

Self-Assembly of Cysteine into Nanofibrils Precedes Cystine Crystal Formation: Implications for Aggregation Inhibition

DS Oluwatoba, P Chakraborty… - … Applied Materials & …, 2023 - ACS Publications
The self-association of metabolites into well-ordered assemblies at the nanoscale has
significant biological and medical implications. The thiol-containing amino acid cysteine …

The Cys/N-degron pathway in the ubiquitin–proteasome system and autophagy

AJ Heo, CH Ji, YT Kwon - Trends in Cell Biology, 2023 - cell.com
The N-degron pathway is a degradative system in which the N-terminal residues of proteins
modulate the half-lives of proteins and other cellular materials. The majority of amino acids …

Knotting terminal ends of mutant T1 lipase with disulfide bond improved structure rigidity and stability

SH Hamdan, J Maiangwa, NG Nezhad, MSM Ali… - Applied Microbiology …, 2023 - Springer
Lipase biocatalysts offer unique properties which are often impaired by low thermal and
methanol stability. In this study, the rational design was employed to engineer a disulfide …

Icy affairs: Understanding recent advancements in the freezing and frozen storage of fish

H Jia, K Roy, J Pan, J Mraz - … in Food Science and Food Safety, 2022 - Wiley Online Library
Freezing methods have evolved over the last 30 years. This review states the effect of
various freezing methods on the quality of fish and seafood. Freezing temperatures …

Alternative antibiotics in dentistry: Antimicrobial peptides

A Griffith, A Mateen, K Markowitz, SR Singer, C Cugini… - Pharmaceutics, 2022 - mdpi.com
The rise of antibiotic resistant bacteria due to overuse and misuse of antibiotics in medicine
and dentistry is a growing concern. New approaches are needed to combat antibiotic …