Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

The success of disease-modifying osteoarthritis drug (DMOAD) development is still elusive.
While there have been successes in preclinical and early clinical studies, phase 3 clinical …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

Magnetic resonance imaging (MRI) is a valuable tool for evaluating musculoskeletal disease
as it offers a range of image contrasts that are sensitive to underlying tissue biochemical …

Although postcontrast imaging has been used for many years in musculoskeletal imaging,
dynamic contrast enhanced (DCE) MRI is not routinely used in many centers around the …

Objective This work aims to study (i) the relationship between body mass index (BMI) and
knee synovial inflammation using non-contrast-enhanced MRI and (ii) the association of …

Background Synovial inflammation is a risk factor for osteoarthritis (OA). But to date, there is
limited information on how inflammation impacts progression of knee OA. Purpose To …

Osteoarthritis (OA) is a chronic, progressive, severely debilitating, and multifactorial joint
disease that is recognized as the most common type of arthritis. During the last decade, it …

Synovitis contributes to the development of osteoarthritis (OA) of the knee. MicroRNAs
regulate joint microenvironment homeostasis and deterioration. This study was undertaken …

Abstract Hypoxia/reoxygenation (H/R) may play an important role via senescence in the
mechanism of osteoarthritis (OA) development. The synovial membrane is highly sensitive to …