Extracellular vesicles: a rising star for therapeutics and drug delivery

S Du, Y Guan, A Xie, Z Yan, S Gao, W Li, L Rao… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …

Exosomes as naturally occurring vehicles for delivery of biopharmaceuticals: insights from drug delivery to clinical perspectives

A Butreddy, N Kommineni, N Dudhipala - Nanomaterials, 2021 - mdpi.com
Exosomes as nanosized vesicles are emerging as drug delivery systems for therapeutics
owing to their natural origin, their ability to mediate intercellular communication, and their …

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

W Zheng, J Rädler, H Sork, Z Niu, S Roudi… - Nature …, 2023 - nature.com
Extracellular vesicles (EVs) are gaining ground as next-generation drug delivery modalities.
Genetic fusion of the protein of interest to a scaffold protein with high EV-sorting ability …

Cell‐specific targeting of extracellular vesicles through engineering the glycocalyx

W Zheng, R He, X Liang, S Roudi, J Bost… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are promising carriers for the delivery of a variety of chemical
and biological drugs. However, their efficacy is limited by the lack of cellular specificity …

Extracellular vesicles as biomarkers and therapeutic tools: from pre-clinical to clinical applications

MC Ciferri, R Quarto, R Tasso - Biology, 2021 - mdpi.com
Simple Summary Extracellular vesicles (EVs) are membrane-bound vesicles released by all
cell types, differing in biogenesis, physical characteristics, and contents. Due to their central …

Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell‐Derived Exosomes in Cell‐Free Therapy

S Chen, F Sun, H Qian, W Xu, J Jiang - Stem cells international, 2022 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely applied to regenerative medicine owing
to their multiple differentiation, self‐renewal, and immunomodulatory abilities. Exosomes are …

Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy

S Shin, H Ko, CH Kim, BK Yoon, S Son, JA Lee… - Nature Materials, 2023 - nature.com
Tumour-derived exosomes (T-EXOs) impede immune checkpoint blockade therapies,
motivating pharmacological efforts to inhibit them. Inspired by how antiviral curvature …

Recent advances in targeted delivery of non-coding RNA-based therapeutics for atherosclerosis

X Li, H Qi, W Cui, Z Wang, X Fu, T Li, H Ma, Y Yang… - Molecular Therapy, 2022 - cell.com
Cardiovascular disease (CVD) has overtaken infectious illnesses as the leading cause of
mortality and disability worldwide. The pathology that underpins CVD is atherosclerosis …

Effect of 2D and 3D culture microenvironments on mesenchymal stem cell-derived extracellular vesicles potencies

GD Kusuma, A Li, D Zhu, H McDonald… - Frontiers in Cell and …, 2022 - frontiersin.org
Therapeutic benefits of mesenchymal stem cells (MSCs) are now widely believed to come
from their paracrine signalling, ie secreted factors such as cytokines, chemokines, and …

Functional extracellular vesicles for regenerative medicine

HY Kim, S Kwon, W Um, S Shin, CH Kim, JH Park… - Small, 2022 - Wiley Online Library
The unique biological characteristics and promising clinical potential of extracellular
vesicles (EVs) have galvanized EV applications for regenerative medicine. Recognized as …