Dietary polyphenols: Regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases

Y Li, Y Peng, Y Shen, Y Zhang, L Liu… - Critical Reviews in Food …, 2023 - Taylor & Francis
Advanced glycation end products (AGEs) are formed in non-enzymatic reaction, oxidation,
rearrangement and cross-linking between the active carbonyl groups of reducing sugars …

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

The amyotrophic lateral sclerosis exposome: recent advances and future directions

SA Goutman, MG Savelieff, DG Jang, J Hur… - Nature Reviews …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration with
typical survival of only 2–5 years from diagnosis. The causes of ALS are multifactorial …

[HTML][HTML] Mining microbes for mental health: determining the role of microbial metabolic pathways in human brain health and disease

S Spichak, TFS Bastiaanssen, K Berding… - Neuroscience & …, 2021 - Elsevier
There is increasing knowledge regarding the role of the microbiome in modulating brain and
behaviour. Indeed, the actions of microbial metabolites are key for appropriate gut-brain …

The relationship between the gut microbiome and neurodegenerative diseases

X Zhu, B Li, P Lou, T Dai, Y Chen, A Zhuge, Y Yuan… - Neuroscience …, 2021 - Springer
Many recent studies have shown that the gut microbiome plays important roles in human
physiology and pathology. Also, microbiome-based therapies have been used to improve …

Comprehensive research on past and future therapeutic strategies devoted to treatment of amyotrophic lateral sclerosis

B Sever, H Ciftci, H DeMirci, H Sever, F Ocak… - International journal of …, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly debilitating fatal neurodegenerative disorder,
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …

[HTML][HTML] Brain modulation by the gut microbiota: From disease to therapy

S Mitra, R Dash, A Al Nishan, SU Habiba… - Journal of Advanced …, 2023 - Elsevier
Background The gut microbiota (GM) and brain are strongly associated, which significantly
affects neuronal development and disorders. GM-derived metabolites modulate neuronal …

[HTML][HTML] Deciphering the gut microbiome in neurodegenerative diseases and metagenomic approaches for characterization of gut microbes

N Singh, V Singh, SN Rai, V Mishra, E Vamanu… - Biomedicine & …, 2022 - Elsevier
The central nervous system has essential role in the regulation of the physiological condition
of the human body. Gut microbes cause several types of gastrointestinal diseases like ulcer …

Gut microbiota interaction with the central nervous system throughout life

J Ojeda, A Ávila, PM Vidal - Journal of Clinical Medicine, 2021 - mdpi.com
During the last years, accumulating evidence has suggested that the gut microbiota plays a
key role in the pathogenesis of neurodevelopmental and neurodegenerative diseases via …

The gut microbiome–brain crosstalk in neurodegenerative diseases

L Ghezzi, C Cantoni, E Rotondo, D Galimberti - Biomedicines, 2022 - mdpi.com
The gut–brain axis (GBA) is a complex interactive network linking the gut to the brain. It
involves the bidirectional communication between the gastrointestinal and the central …