Growth differentiation factor 11: A new hope for the treatment of cardiovascular diseases

Y Shao, Y Wang, J Xu, Y Yuan, D Xing - Cytokine & Growth Factor Reviews, 2023 - Elsevier
ABSTRACT Growth differentiation factor 11 (GDF11) is a member of the transforming growth
factor-β superfamily that has garnered significant attention due to its anti-cardiac aging …

The regulatory effect of growth differentiation factor 11 on different cells

Y Shao, T Liu, X Wen, R Zhang, X Liu… - Frontiers in …, 2023 - frontiersin.org
Growth differentiation factor 11 (GDF11) is one of the important factors in the
pathophysiological process of animals. It is widely expressed in many tissues and organs of …

[HTML][HTML] Growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases?

Y Ma, Y Liu, F Han, H Qiu, J Shi, N Huang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Abstract Growth differentiation factor 11 (GDF11), a member of the transforming growth
factor β superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 …

GDF11 mitigates high glucose-induced cardiomyocytes apoptosis by inhibiting the ALKBH5-FOXO3-CDR1as/Hippo signaling pathway

Y Shao, M Li, Y Wang, Y Qu, M Gong, Q Yu… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Diabetic cardiomyopathy remains a formidable health challenge with a high mortality rate
and no targeted treatments. Growth differentiation factor 11 (GDF11) has shown promising …

Role of circulating molecules in age-related cardiovascular and metabolic disorders

YT Hsiao, I Shimizu, Y Yoshida, T Minamino - Inflammation and …, 2022 - Springer
Studies analyzing heterochronic parabiosis mice models showed that molecules in the
blood of young mice rejuvenate aged mice. Therefore, blood-based therapies have become …

Hydrogen sulfide antagonizes formaldehyde-induced ferroptosis via preventing ferritinophagy by upregulation of GDF11 in HT22 cells

YH Tang, L Wu, HL Huang, PP Zhang, W Zou, XQ Tang… - Toxicology, 2023 - Elsevier
Formaldehyde (FA) has neurotoxic characteristics and causes neurodegenerative disease.
Our previous study demonstrated the neuroprotective effects of hydrogen sulfide (H 2 S) on …

GDF11 Regulates PC12 neural stem cells via ALK5-Dependent PI3K-Akt signaling pathway

Z Wang, P Jiang, F Liu, X Du, L Ma, S Ye… - International Journal of …, 2022 - mdpi.com
Growth differentiation factor 11 (GDF11), belonging to the transforming factor-β superfamily,
regulates anterior-posterior patterning and inhibits neurogenesis during embryonic …

Growth differentiation factor 11 regulates high glucose-induced cardiomyocyte pyroptosis and diabetic cardiomyopathy by inhibiting inflammasome activation

J Zhang, G Wang, Y Shi, X Liu, S Liu, W Chen… - Cardiovascular …, 2024 - Springer
Background Diabetic cardiomyopathy (DCM) is a crucial complication of long-term chronic
diabetes that can lead to myocardial hypertrophy, myocardial fibrosis, and heart failure …

The role of hydrogen sulfide regulation of ferroptosis in different diseases

J Lian, Y Chen, Y Zhang, S Guo, H Wang - Apoptosis, 2024 - Springer
Ferroptosis is a programmed cell death that relies on iron and lipid peroxidation. It differs
from other forms of programmed cell death such as necrosis, apoptosis and autophagy …

GDF11 is a novel protective factor against vascular calcification

Y Sheng, C Zhang, Y Liu, B Xu, T Jin, T Ye… - Journal of …, 2022 - journals.lww.com
Vascular calcification (VC) occurs via an active cell-mediated process, which involves
osteogenic differentiation, apoptosis, and phenotypic transformation of vascular smooth …