Sickle cell disease (SCD) is the most common hereditary disorder of hemoglobin (Hb),
which affects approximately a million people worldwide. It is characterized by a single …

Sickle cell disease (SCD) is an inherited monogenic disorder and the most common severe
hemoglobinopathy in the world. SCD is characterized by a point mutation in the β-globin …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

Chronic inflammation has emerged as an important pathogenic mechanism in sickle cell
disease (SCD). One component of this inflammatory response is oxidant stress mediated by …

Background & aims Nitric oxide bioactivity (NO) from endothelial NO synthase (eNOS)
importantly contributes to the maintenance of vascular homeostasis, and reduced eNOS …

The aims of this review are to highlight the mechanisms and consequences of iron
distribution that are most relevant to transfused sickle cell disease (SCD) patients and to …

Chronic hemolysis, enhanced oxidative stress, and decreased nitric oxide (NO)
bioavailability promote vasculopathy in sickle cell anemia (SCA). Oxidative stress and NO …

Oxidative stress is an important contributor to the pathophysiology of sickle cell disease. The
pathways involved are complex and interlinked. L-glutamine is an amino acid with myriad …

Polymerization of deoxy sickle cell hemoglobin (HbS) is well recognized as the primary
event that triggers the classic cycles of sickling/unsickling of patients red blood cells (RBCs) …

Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated
with global morbidity and early mortality. More effective and inexpensive therapies are …