Immunomodulatory mechanisms of mesenchymal stem cells and their potential clinical applications

Y Huang, Q Wu, PKH Tam - International Journal of Molecular Sciences, 2022 - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent stem cells with the capacity of self-renewal,
homing, and low immunogenicity. These distinct biological characteristics have already …

Systematic review and meta-analysis of cell therapy for COVID-19: global clinical trial landscape, published safety/efficacy outcomes, cell product manufacturing and …

PS Couto, N Al-Arawe, IS Filgueiras… - Frontiers in …, 2023 - frontiersin.org
During the pandemic of severe respiratory distress syndrome coronavirus 2 (SARS-CoV2),
many novel therapeutic modalities to treat Coronavirus 2019 induced disease (COVID-19) …

Effectiveness and safety of normoxic allogenic umbilical cord mesenchymal stem cells administered as adjunctive treatment in patients with severe COVID-19

B Soetjahjo, RG Malueka, A Nurudhin, Purwoko… - Scientific Reports, 2023 - nature.com
Inflammatory response in COVID-19 contributes greatly to disease severity. Mesenchymal
Stem Cells (MSCs) have the potential to alleviate inflammation and reduce mortality and …

Pathogenic role of adipose tissue-derived mesenchymal stem cells in obesity and obesity-related inflammatory diseases

J Pestel, F Blangero, A Eljaafari - Cells, 2023 - mdpi.com
Adipose tissue-derived mesenchymal stem cells (ASCs) are adult stem cells, endowed with
self-renewal, multipotent capacities, and immunomodulatory properties, as mesenchymal …

Human mesenchymal stem cell therapy in severe COVID-19 patients: 2-year follow-up results of a randomized, double-blind, placebo-controlled trial

TT Li, B Zhang, H Fang, M Shi, WQ Yao, Y Li… - …, 2023 - thelancet.com
Background Long-term effects of human mesenchymal stem cell (MSC) treatment on COVID-
19 patients have not been fully characterized. The aim of this study was to evaluate the …

Mesenchymal stem cell therapy for COVID-19 infection

SMM Alavi-Dana, Y Gholami, M Meghdadi… - …, 2024 - Springer
COVID-19 emerged in December 2019 in Wuhan, China, spread worldwide rapidly, and
caused millions of deaths in a short time. Many preclinical and clinical studies were …

[HTML][HTML] Clinical progress in MSC-based therapies for the management of severe COVID-19

M Rossello-Gelabert, A Gonzalez-Pujana… - Cytokine & Growth …, 2022 - Elsevier
Considering the high impact that severe Coronavirus disease 2019 (COVID-19) cases still
pose on public health and their complex pharmacological management, the search for new …

Effect and safety of mesenchymal stem cells for patients with COVID‐19: Systematic review and meta‐analysis with trial sequential analysis

Z Zhang, S Shao, X Liu, Z Tong - Journal of Medical Virology, 2023 - Wiley Online Library
The objective of this study was to assess whether mesenchymal stem cells (MSCs) therapy
could offer survival advantages for patients with novel coronavirus disease 2019 (COVID …

Efficient delivery of mesenchymal stem/stromal cells to injured liver by surface PEGylation

Y Takayama, K Kusamori, Y Katsurada… - Stem Cell Research & …, 2023 - Springer
Background Mesenchymal stem/stromal cells (MSCs) have been used in clinical trials for
various diseases. These have certain notable functions such as homing to inflammation …

Effectiveness of RCTs Pooling Evidence on Mesenchymal Stem Cell (MSC) Therapeutic Applications During COVID-19 Epidemic: A Systematic Review

UR Kandula, AD Wake - Biologics: Targets and Therapy, 2023 - Taylor & Francis
Background Global pandemic identified as coronavirus disease 2019 (COVID-19) has
resulted in a variety of clinical symptoms, from asymptomatic carriers to those with severe …