The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …

The molecular mechanisms and signalling pathways that regulate the in vitro preservation of
distinct pluripotent stem cell configurations, and their induction in somatic cells by direct …

Classic embryological experiments have established that the early mouse embryo develops
via sequential lineage bifurcations. The first segregated lineage is the trophectoderm …

Age-related osteoporosis is characterized by the deterioration in bone volume and strength,
partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) …

Zygotic genome activation (ZGA) marks the beginning of the embryonic program for a
totipotent embryo, which gives rise to the inner cell mass (ICM) where pluripotent epiblast …

Current human pluripotent stem cells lack the transcription factor circuitry that governs the
ground state of mouse embryonic stem cells (ESC). Here, we report that short-term …

Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier," naive" state of pluripotency may …

Here we delineate the ontogeny of the mammalian endoderm by generating 112,217 single-
cell transcriptomes, which represent all endoderm populations within the mouse embryo …

Stem cells self-renew and generate specialized progeny through differentiation, but vary in
the range of cells and tissues they generate, a property called developmental potency …

Technologies allowing for specific regulation of endogenous genes are valuable for the
study of gene functions and have great potential in therapeutics. We created the CRISPR-on …