The study of chronic pain continues to generate ever-increasing numbers of publications,
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …

Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis,
nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a …

Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …

Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …

Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several
antineoplastics. It can lead to detrimental dose reductions and discontinuation of treatment …

Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …

Reactive oxygen species (ROS) contribute to tissue damage and remodelling mediated by
the inflammatory response after injury. Here we show that ROS, which promote axonal …

Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

Vincristine-induced peripheral neurotoxicity (VIPN) is a very common side effect of
vincristine chemotherapy among pediatric patients with cancer. Neuropathy may be sensory …

Following peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in
dorsal root ganglia (DRG) sensory neurons. Here we show that DRG neuron cell bodies …