Catecholamines for inflammatory shock: a Jekyll-and-Hyde conundrum

DT Andreis, M Singer - Intensive care medicine, 2016 - Springer
Catecholamines are endogenous neurosignalling mediators and hormones. They are
integral in maintaining homeostasis by promptly responding to any stressor. Their synthetic …

β-blockade use for traumatic injuries and immunomodulation: a review of proposed mechanisms and clinical evidence

TJ Loftus, PA Efron, LL Moldawer, AM Mohr - Shock, 2016 - journals.lww.com
Sympathetic nervous system activation and catecholamine release are important events
following injury and infection. The nature and timing of different pathophysiologic insults …

Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist

D Han, X Li, S Li, T Su, L Fan, WS Fan, HY Qiao… - Free Radical Biology …, 2017 - Elsevier
Myocardial injury and dysfunction are critical manifestations of sepsis. Previous studies have
reported that liver X receptor (LXR) activation is protective during sepsis. However, whether …

Adrenergic and glucocorticoid receptor antagonists reduce ozone-induced lung injury and inflammation

AR Henriquez, SJ Snow, MC Schladweiler… - Toxicology and applied …, 2018 - Elsevier
Recent studies showed that the circulating stress hormones, epinephrine and
corticosterone/cortisol, are involved in mediating ozone-induced pulmonary effects through …

Similar metabolic, innate immunity, and adipokine profiles in adult and pediatric sepsis versus systemic inflammatory response syndrome—a pilot study

T Tavladaki, AM Spanaki, H Dimitriou… - Pediatric Critical Care …, 2017 - journals.lww.com
Objectives: To examine whether the septic profiles of heat shock protein 72, heat shock
protein 90α, resistin, adiponectin, oxygen consumption, CO 2 production, energy …

Adrenoceptors as potential target for add-on immunomodulatory therapy in multiple sclerosis

I Pilipović, Z Stojić-Vukanić, G Leposavić - Pharmacology & Therapeutics, 2023 - Elsevier
This review summarizes recent findings related to the role of the sympathetic nervous
system (SNS) in pathogenesis of multiple sclerosis (MS) and its commonly used …

Misdirected sympathy: the role of sympatholysis in sepsis and septic shock

JA Ferreira, BD Bissell - Journal of Intensive Care Medicine, 2018 - journals.sagepub.com
The spectrum of sepsis and septic shock remains a highly prevalent disease state, carrying
a high risk of morbidity and mortality. The sympathetic nervous system (SNS) plays an …

β-Adrenoceptor blockade moderates neuroinflammation in male and female EAE rats and abrogates sexual dimorphisms in the major neuroinflammatory pathways by …

I Pilipović, Z Stojić-Vukanić, I Prijić, N Jasnić… - Cellular and Molecular …, 2023 - Springer
Our previous studies showed more severe experimental autoimmune encephalomyelitis
(EAE) in male compared with female adult rats, and moderating effect of propranolol …

[HTML][HTML] Propranolol diminished severity of rat EAE by enhancing immunoregulatory/protective properties of spinal cord microglia

I Pilipović, Z Stojić-Vukanić, I Prijić, N Jasnić… - Neurobiology of …, 2020 - Elsevier
Sympathetic dysfunction is suggested to contribute to development of multiple sclerosis and
experimental autoimmune encephalomyelitis (EAE) alike. Considering important role of …

Local sympathetic neurons promote neutrophil egress from the bone marrow at the onset of acute inflammation

T Ao, J Kikuta, T Sudo, Y Uchida… - International …, 2020 - academic.oup.com
The sympathetic nervous system plays critical roles in the differentiation, maturation and
recruitment of immune cells under homeostatic conditions, and in responses to …