Living organisms are continuously exposed to xenobiotics. The major phase of enzymatic
detoxification in many species is the conjugation of activated xenobiotics to reduced …

Cisplatin is an effective chemotherapeutic drug whose clinical use and efficacy are limited
by its nephrotoxicity, which affects mainly the renal tubules and vasculature. It accumulates …

Nephrotoxicity remain a major life-threatening complication in cancer patients on cisplatin
chemotherapy. In this study, we investigated the protective effect and possible cellular …

This study was designed to examine the contribution of oxidative stress in gastrointestinal
disorders after an intraperitoneal administration of 5 fluorouracil (5-FU; 100 mg/kg of body …

Abstract Serotonin (5-HT) has been implicated as a key driver of liver fibrosis, acting via 5-
HT2 receptor activation in the hepatic stellate cells. The current study was conducted to …

Cisplatin causes infertility due to ovarian toxicity. The toxicity mechanism is unknown, but
evidence suggests oxidative stress. In this study, the effect of mirtazapine on cisplatin …

Aim Cisplatin chemotherapy is associated with neurotoxicity, and oxidative stress might play
an important role in the pathogenesis. Mirtazapine may be a preventative agent via its less …

Mirtazapine is an antidepressant with prominent antioxidant effects. Chrysin, a natural
flavone, exhibits multiple pharmacological actions. This study was designed to investigate …

OBJECTIVE: The aim of our study was to investigate the protective effect of taxifolin on
ovarian damage and reproductive dysfunction created by cisplatin administration …

Background Cisplatin (a platinum-compound) is a anti-neoplastic drug used in the treatment
of various cancers but eventually results in severe adverse effects namely nephrotoxicity or …