[HTML][HTML] Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms

H Slika, H Mansour, N Wehbe, SA Nasser… - Biomedicine & …, 2022 - Elsevier
Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen
species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants …

[HTML][HTML] New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

HS Kim, MJ Quon, J Kim - Redox biology, 2014 - Elsevier
Green tea is rich in polyphenol flavonoids including catechins. Epigallocatechin 3-gallate
(EGCG) is the most abundant and potent green tea catechin. EGCG has been extensively …

Reactive oxygen species in cancer

GY Liou, P Storz - Free radical research, 2010 - Taylor & Francis
Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers,
where they promote many aspects of tumour development and progression. However …

Tea polyphenols for health promotion

N Khan, H Mukhtar - Life sciences, 2007 - Elsevier
People have been consuming brewed tea from the leaves of the Camellia sinensis plant for
almost 50 centuries. Although health benefits have been attributed to tea, especially green …

Polyphenols and mitochondria: an update on their increasingly emerging ROS-scavenging independent actions

C Sandoval-Acuña, J Ferreira, H Speisky - Archives of biochemistry and …, 2014 - Elsevier
Polyphenols, ubiquitously present in fruits and vegetables, have been traditionally viewed
as antioxidant molecules. Such contention emerged, mainly from their well established in …

The role of antioxidant versus pro‐oxidant effects of green tea polyphenols in cancer prevention

SC Forester, JD Lambert - Molecular nutrition & food research, 2011 - Wiley Online Library
Consumption of green tea (Camellia sinensis) may provide protection against chronic
diseases, including cancer. Green tea polyphenols are believed to be responsible for this …

Chemico-biological aspects of (−)-epigallocatechin-3-gallate (EGCG) to improve its stability, bioavailability and membrane permeability: Current status and future …

R Sahadevan, S Singh, A Binoy… - Critical Reviews in Food …, 2023 - Taylor & Francis
Natural products have been a bedrock for drug discovery for decades.(−)-Epigallocatechin-3-
gallate (EGCG) is one of the widely studied natural polyphenolic compounds derived from …

Prooxidant effects of epigallocatechin‐3‐gallate in health benefits and potential adverse effect

J Ouyang, K Zhu, Z Liu, J Huang - Oxidative Medicine and …, 2020 - Wiley Online Library
Epigallocatechin‐3‐gallate (EGCG) is the major polyphenolic compound present in green
tea and is generally regarded as an effective antioxidant. However, its chemical reactivity …

Polyphenols in food: Cancer prevention and apoptosis induction

A Sharma, M Kaur, JK Katnoria… - Current medicinal …, 2018 - ingentaconnect.com
Polyphenols are a group of water-soluble organic compounds, mainly of natural origin. The
compounds having about 5-7 aromatic rings and more than 12 phenolic hydroxyl groups are …

Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models

R Wei, L Mao, P Xu, X Zheng, RM Hackman… - Food & function, 2018 - pubs.rsc.org
Numerous studies propose that epigallocatechin-3-gallate (EGCG), an abundant polyphenol
in green tea, has anti-cancer properties. However, its mechanism of action in breast cancer …