Infectious diseases continue to be one of the major contributors to human morbidity. The
rapid rate at which pathogenic microorganisms have developed resistance against frontline …

Hereunder, we highlight bacterial membrane anionic lipids as attractive targets in the design
of antibacterial drugs which can be effective against both Gram-positive and Gram-negative …

The benzophenone scaffold represents a ubiquitous structure in medicinal chemistry
because it is found in several naturally occurring molecules which exhibit a variety of …

Infectious diseases remain significant health concerns worldwide, and resistance is
particularly common in patients with tuberculosis caused by Mycobacterium tuberculosis …

Minor groove binders are small molecules that form strong complexes with the minor groove
of DNA. There are several structural types of which distamycin and netropsin analogues …

The rapid growth of antimicrobial resistance against several frontline antibiotics has
encouraged scientists worldwide to develop new alternatives with unique mechanisms of …

Tuberculosis (TB) poses an enduring threat to global health. Consistently ranked among the
top 10 causes of death worldwide since 2000, TB has now exceeded HIV-AIDS in terms of …

The rise of antibiotic resistant bacteria requires unconventional strategies toward efficient
chemotherapeutic agents, preferably with alternative mechanisms of action. The bacterial …

Infections caused by drug resistant and/or slow-growing bacteria are increasingly becoming
some of the greatest challenges of health organizations worldwide. The decrease in the …

Mesoporous silica nanomaterials show great potential to deliver chemotherapeutics for
cancer treatment. The key challenges in the development of injectable mesoporous silica …