Research priorities towards precision antibiotic therapy to improve patient care

ZP Bulman, SG Wicha, EI Nielsen, JR Lenhard… - The Lancet …, 2022 - thelancet.com
Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …

Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

TJ Kochan, SH Nozick, RL Medernach… - BMC infectious …, 2022 - Springer
Background Klebsiella pneumoniae strains have been divided into two major categories:
classical K. pneumoniae, which are frequently multidrug-resistant and cause hospital …

Klebsiella pneumoniae clinical isolates with features of both multidrug-resistance and hypervirulence have unexpectedly low virulence

TJ Kochan, SH Nozick, A Valdes, SD Mitra… - Nature …, 2023 - nature.com
Klebsiella pneumoniae has been classified into two types, classical K. pneumoniae (cKP)
and hypervirulent K. pneumoniae (hvKP). cKP isolates are highly diverse and important …

Characterization of Carbapenem-Resistant K. Pneumoniae Isolated from Intensive Care Units of Zagazig University Hospitals

NHM Gandor, GES Amr, SMS Eldin Algammal… - Antibiotics, 2022 - mdpi.com
The advent of carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant
challenge to public health, as carbapenems are typically employed as a last resort to treat …

Metagenomics of virus diversities in solid-state brewing process of traditional Chinese vinegar

Z Yu, Y Ma, Y Guan, Y Zhu, K Wang, Y Wang, P Liu… - Foods, 2022 - mdpi.com
Traditional Chinese vinegar offers an exceptional flavor and rich nutrients due to its unique
solid-state fermentation process, which is a multiple microbial fermentation system including …

Genomic characteristics of antimicrobial resistance and virulence factors of carbapenem-resistant Stutzerimonas nitrititolerans isolated from the clinical specimen

L Shi, Y Zhang, Y Zhan, X Wang, J Xu, H Wang… - BMC microbiology, 2024 - Springer
Background Stutzerimonas nitrititolerans (S. nitrititolerans) is a rare human pathogenic
bacterium and has been inadequately explored at the genomic level. Here, we report the …

Prediction of antimicrobial resistance in Klebsiella pneumoniae using genomic and metagenomic next-generation sequencing data

X Zhou, M Yang, F Chen, L Wang, P Han… - Journal of …, 2024 - academic.oup.com
Objectives Klebsiella pneumoniae is a significant pathogen with increasing resistance and
high mortality rates. Conventional antibiotic susceptibility testing methods are time …

Holistic understanding of trimethoprim resistance in Streptococcus pneumoniae using an integrative approach of genome-wide association study, resistance …

NP Pham, H Gingras, C Godin, J Feng, A Groppi… - Mbio, 2024 - journals.asm.org
Antimicrobial resistance (AMR) is a public health threat worldwide. Next-generation
sequencing (NGS) has opened unprecedented opportunities to accelerate AMR mechanism …

Virulence, antimicrobial resistance, and molecular characteristics of carbapenem-resistant Klebsiella pneumoniae in a hospital in Shijiazhuang City from China

Y Guo, F Liu, Y Zhang, X Wang, W Gao, B Xu… - International …, 2023 - Springer
Carbapenem-resistant Klebsiella pneumoniae (CRKP), as one of the most common drug-
resistant bacteria threatening human health, is hyper-resistant to multiple antimicrobial …

Longitudinal analysis within one hospital in sub-Saharan Africa over 20 years reveals repeated replacements of dominant clones of Klebsiella pneumoniae and …

E Heinz, O Pearse, A Zuza, S Bilima, C Msefula… - Genome Medicine, 2024 - Springer
Background Infections caused by multidrug-resistant gram-negative bacteria present a
severe threat to global public health. The WHO defines drug-resistant Klebsiella …