Studies of alterations in histone methylation in cancer have led to the identification of histone
methyltransferases and demethylases as novel targets for therapy. Lysine-specific …

Platinum compounds (cisplatin and carboplatin) represent the most active anticancer agents
in clinical use both of lung cancer in mono-and combination therapies. However, platinum …

LSD1 (lysine specific demethylase; also known as KDM1A), the first histone demethylase
discovered, regulates cell-fate determination and is overexpressed in multiple cancers …

Hematopoiesis requires finely tuned regulation of gene expression at each stage of
development. The regulation of gene transcription involves not only individual transcription …

There is an unmet need to overcome nongenetic therapy-resistance to improve outcomes in
AML, especially post-myeloproliferative neoplasm (MPN) secondary (s) AML. Studies …

Most tumor types either fail to respond or become resistant to kinase inhibitors, often
because of compensatory prosurvival pathways in the cancer cell's broader signaling …

Growth factor independence 1 (GFI1) and the closely related protein GFI1B are small
nuclear proteins that act as DNA binding transcriptional repressors. Both recognize the …

Over the past decades, our molecular understanding of acute myeloid leukemia (AML)
pathogenesis dramatically increased, thanks also to the advent of next-generation …

Epigenetic variations can play remarkable roles in different normal and abnormal situations.
Such variations have been shown to have a direct role in the pathogenesis of various …

Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder
characterized by progressive paralysis due to motor neuron degeneration. It has been …