This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines.
Numerous studies have implicated that inflammatory cytokines exert important effects with …

Anagen stage hair follicles (HFs) exhibit “immune privilege (IP)” from the level of the bulge
downwards to the bulb. Both passive and active IP mechanisms protect HFs from …

Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture
of how MHC class I and MHC class II molecules really work. This is a story of the proteases …

Antigenic peptide-loaded MHC class II molecules (peptide–MHC class II) are constitutively
expressed on the surface of professional antigen-presenting cells (APCs), including …

The molecular details of antigen processing and presentation by MHC class I and class II
molecules have been studied extensively for almost three decades. Although the basic …

Interleukin (IL)-10 is the most important cytokine with anti-inflammatory properties besides
TGF-β and IL-35. It is produced by activated immune cells, in particular monocytes …

Abstract Interleukin-10 (IL-10) is arguably the most potent anti-inflammatory cytokine. It is
produced by almost all the innate and adaptive immune cells. These cells also serve as its …

The tumor microenvironment is a complex milieu of tumor and host cells. Host cells can
include tumor-reactive T cells capable of killing tumor cells. However, more frequently the …

Dendritic cells are at the center of immune responses. They are defined by their ability to
sense the environment, take up and process antigen, migrate to secondary lymphoid …

Highlights•IL-10 inhibits T cell activation by suppressing APC function.•IL-10 suppresses
TLR-signaling in dendritic cells and monocytes/macrophages.•IL-10 suppresses IFNγ …