Plants as a source of anticancer agents: From bench to bedside

WH Talib, S Daoud, AI Mahmod, RA Hamed, D Awajan… - Molecules, 2022 - mdpi.com
Cancer is the second leading cause of death after cardiovascular diseases. Conventional
anticancer therapies are associated with lack of selectivity and serious side effects. Cancer …

[HTML][HTML] Antioxidant and anti-inflammatory agents in chronic liver diseases: Molecular mechanisms and therapy

CY Zhang, S Liu, M Yang - World Journal of Hepatology, 2023 - ncbi.nlm.nih.gov
Chronic liver disease (CLD) is a continuous process that causes a reduction of liver function
lasting more than six months. CLD includes alcoholic liver disease (ALD), non-alcoholic fatty …

Curative effects of crocin in ulcerative colitis via modulating apoptosis and inflammation

GA Albalawi, MZ Albalawi, KT Alsubaie… - International …, 2023 - Elsevier
Ulcerative colitis (UC) is an inflammatory bowel disease with characteristic inflammation to
mucosal cells in rectum and colon leading to lesions in mucosa and submucosa. Moreover …

Application of cinnamic acid in the structural modification of natural products: A review

H Deng, Q Xu, HY Guo, X Huang, F Chen, L Jin… - Phytochemistry, 2023 - Elsevier
Natural products can generally exhibit a variety of biological activities, but most show
mediocre performance in preliminary activity evaluation. Natural products often require …

Therapeutic effects of genistein in experimentally induced ulcerative colitis in rats via affecting mitochondrial biogenesis

TS Alharbi, ZS Alshammari, ZN Alanzi… - Molecular and Cellular …, 2024 - Springer
Ulcerative colitis (UC) is an inflammatory bowel disease that affects the mucosa of the colon,
resulting in severe inflammation and ulcers. Genistein is a polyphenolic isoflavone present …

Genistein ameliorated experimentally induced gastric ulcer in rats via inhibiting gastric tissues fibrosis by modulating Wnt/β-catenin/TGF-β/PKB pathway

HM Hassan, NM Alatawi, A Bagalagel, R Diri… - Redox …, 2023 - Taylor & Francis
Objectives Gastric ulcer (GU) is a prevalent chronic digestive disease affecting about 10% of
the world's population leading to gastrointestinal perforation and bleeding. Genistein is a …

[HTML][HTML] Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease

B Li, Y Wang, X Jiang, H Du, Y Shi, M Xiu, Y Liu… - Biomedicine & …, 2023 - Elsevier
Inflammatory bowel disease (IBD) is a special chronic intestinal inflammatory disease, which
is mainly divided into Crohn's disease (CD) and ulcerative colitis (UC). Its occurrence is a …

[HTML][HTML] Recent advancements in the small-molecule drugs for hepatocellular carcinoma (HCC): Structure-activity relationships, pharmacological activities, and the …

Q Deng, Y Huang, J Zeng, X Li, X Zheng, L Guo… - Biomedicine & …, 2024 - Elsevier
Background and aims Hepatocellular carcinoma (HCC) is one of the most common
malignancies in the world and the sixth leading cause of cancer death worldwide, and it is …

[HTML][HTML] Antitumor activity of ligustilide against Ehrlich solid carcinoma in rats via inhibition of proliferation and activation of autophagy

AF Alshehri, AE Khodier, MM Al-Gayyar - Cureus, 2023 - ncbi.nlm.nih.gov
Background Cancer is the second-leading cause of death worldwide. According to a 2018
WHO report, 9.6 million deaths occurred globally due to cancer. Ehrlich carcinoma is …

Therapeutic aspects of genistein based on recent advances and challenges

A Mirzaei, M Nikzaban - Micro Nano Bio Aspects, 2023 - mnba-journal.com
The most promising avenues for improving conventional drugs are those based on
biocompatible organic compounds. These bioactive compounds can be isolated from …