Liposomes have a wide array of uses that have been continuously expanded and improved
upon since first being observed to self-assemble into vesicular structures. These …

Over the last four decades, intense research has focused on the effects of small organic
compounds that noncovalently bind to nucleic acids. These interactions have been shown to …

Liquid–liquid phase separation is responsible for formation of P granules, nucleoli, and
other membraneless subcellular organelles composed of RNA and proteins. Efforts to …

Revised Manuscript Received August 14, 1989 abstract: The anticancer drugs adriamycin
and daunomycin have each been crystallized with the DNA sequence d (CGATCG) and the …

Biogenic polyamines, such as putrescine, spermidine, and spermine are small organic
polycations involved in numerous diverse biological processes. These compounds play an …

The anticancer activity of DNA intercalators is related to their ability to intercalate into the
DNA duplex with high affinity, thereby interfering with DNA replication and transcription …

To estimate the polyamine distribution in bovine lymphocytes and rat liver, the binding
constants (K) for DNA, RNA, phospholipid, and ATP were determined under the conditions …

We describe a very accurate addition (called structure X here) to the B-DNA dodecamer
family of X-ray structures. Our results confirm the observation of Drew and Dickerson [(1981) …

Biogenic amines are organic polycations derived from aromatic or cationic amino acids. All
of them have one or more positive charges and a hydrophobic skeleton. Nature has evolved …

Stable cationic lipid/DNA complexes were formed by solubilizing cationic liposomes with 1%
octylglucoside and complexing a DNA plasmid with the lipid in the presence of detergent …