Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases

E Plazas, DR Muñoz - Pharmacological Research, 2022 - Elsevier
Complex diseases such as neurodegenerative disorders and cancer constitute a growing
public health problem due to the rising incidence and lack in effective therapies. Since …

Heroin and its metabolites: relevance to heroin use disorder

MS Milella, G D'Ottavio, S De Pirro, M Barra… - Translational …, 2023 - nature.com
Heroin is an opioid agonist commonly abused for its rewarding effects. Since its synthesis at
the end of the nineteenth century, its popularity as a recreational drug has ebbed and …

Multiproxy study of 7500-year-old wooden sickles from the Lakeshore Village of La Marmotta, Italy

N Mazzucco, M Mineo, D Arobba, R Caramiello… - Scientific reports, 2022 - nature.com
The lakeshore site of La Marmotta is one of the most important Early Neolithic sites of
Mediterranean Europe. The site is famous for the exceptional preservation of organic …

Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids

Y Tian, L Kong, Q Li, Y Wang, Y Wang, Z An… - Natural product …, 2024 - pubs.rsc.org
Covering: up to June 2024 Benzylisoquinoline alkaloids (BIAs) represent a diverse class of
plant specialized metabolites derived from L-tyrosine, exhibiting significant pharmacological …

Insights into opium poppy (Papaver spp.) genetic diversity from genotyping-by-sequencing analysis

UVT Hong, M Tamiru-Oli, B Hurgobin, CR Okey… - Scientific Reports, 2022 - nature.com
Opium poppy (Papaver somniferum) is one of the world's oldest medicinal plants and a
versatile model system to study secondary metabolism. However, our knowledge of its …

Direct evidence of the use of multiple drugs in Bronze Age Menorca (Western Mediterranean) from human hair analysis

E Guerra-Doce, C Rihuete-Herrada, R Micó, R Risch… - Scientific reports, 2023 - nature.com
Human hair dated to Late Prehistory is exceedingly rare in the Western Mediterranean.
Archaeological excavations in the Bronze Age burial and cult cave of Es Càrritx, in Menorca …

A morphometric approach to track opium poppy domestication

A Jesus, V Bonhomme, A Evin, S Ivorra, R Soteras… - Scientific reports, 2021 - nature.com
Opium poppy (Papaver somniferum L. subsp. somniferum) was likely domesticated in the
Western Mediterranean, where its putative wild ancestor is indigenous, and then spread to …

Genomic and cell-specific regulation of benzylisoquinoline alkaloid biosynthesis in opium poppy

UVT Hong, M Tamiru-Oli, B Hurgobin… - Journal of …, 2025 - academic.oup.com
Opium poppy is a crop of great commercial value as a source of several opium alkaloids for
the pharmaceutical industries including morphine, codeine, thebaine, noscapine, and …

A revised tribal classification of Papaveraceae (poppy family) based on molecular and morphological data

HW Peng, KL Xiang, L Lian, B Liu, AS Erst, TG Gao… - Taxon, 2024 - Wiley Online Library
Papaveraceae, commonly known as the poppy family, contains many species with
horticultural and/or pharmaceutical importance and has been the subject of various …

A cornucopia of diversity—Ranunculales as a model lineage

RanOmics group, A Becker, JB Bachelier… - Journal of …, 2024 - academic.oup.com
The Ranunculales are a hyperdiverse lineage in many aspects of their phenotype, including
growth habit, floral and leaf morphology, reproductive mode, and specialized metabolism …