The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans
PB Danielson - Current drug metabolism, 2002 - ingentaconnect.com
Cytochrome P450s comprise a superfamily of heme-thiolate proteins named for the spectral
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …
Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation
EL LeCluyse - European journal of pharmaceutical sciences, 2001 - Elsevier
Primary cultures of human hepatocytes have been used extensively by both academic and
industrial laboratories for evaluating the hepatic disposition of drugs and other xenobiotics …
industrial laboratories for evaluating the hepatic disposition of drugs and other xenobiotics …
Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells
C Rodríguez-Antona, MT Donato, A Boobis… - Xenobiotica, 2002 - Taylor & Francis
1. Cultured hepatic cells have reduced cytochrome P450 (CYP) activities in comparison with
human liver, but the mechanism (s) that underlies this circumstance is not clear. We …
human liver, but the mechanism (s) that underlies this circumstance is not clear. We …
Tissue distribution of MRNA expression of human cytochrome P450 isoforms assessedby high-sensitivity real-time reverse transcription PCR
M Nishimura, H Yaguti, H Yoshitsugu, S Naito… - Yakugaku …, 2003 - jstage.jst.go.jp
Pairs of forward and reverse primers and TaqMan probes specific to each human
cytochrome P450 isoform were prepared. Analysis of the mRNA level of each CYP isoform …
cytochrome P450 isoform were prepared. Analysis of the mRNA level of each CYP isoform …
Significance of the minor cytochrome P450 3A isoforms
AK Daly - Clinical pharmacokinetics, 2006 - Springer
Abstract Cytochrome P450 (CYP) 3A4 is responsible for most CYP3A-mediated drug
metabolism but the minor isoforms CYP3A5, CYP3A7 and CYP3A43 also contribute …
metabolism but the minor isoforms CYP3A5, CYP3A7 and CYP3A43 also contribute …
[HTML][HTML] Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells
R Taléns-Visconti, A Bonora, R Jover… - World journal of …, 2006 - ncbi.nlm.nih.gov
AIM: To investigate and compare the hepatogenic transdifferentiation of adipose tissue-
derived stem cells (ADSC) and bone marrow-derived mesenchymal stem cells (BMSC) in …
derived stem cells (ADSC) and bone marrow-derived mesenchymal stem cells (BMSC) in …
Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies
Gaining knowledge on the metabolism of a drug, the enzymes involved and its inhibition or
induction potential is a necessary step in pharmaceutical development of new compounds …
induction potential is a necessary step in pharmaceutical development of new compounds …
[引用][C] Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties
S Wilkening, F Stahl, A Bader - Drug metabolism and disposition, 2003 - ASPET