Fibrosis is the final common pathway of inflammatory diseases in various organs. The inflammasomes play an important role in the progression of fibrosis as innate immune …
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
KH Dinnon III, SR Leist, K Okuda, H Dang… - Science translational …, 2022 - science.org
A subset of individuals who recover from coronavirus disease 2019 (COVID-19) develop post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
HY Chung, DH Kim, EK Lee, KW Chung… - Aging and …, 2019 - ncbi.nlm.nih.gov
Age-associated chronic inflammation is characterized by unresolved and uncontrolled inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …
X Li, W Zhang, Q Cao, Z Wang, M Zhao, L Xu… - Cell death …, 2020 - nature.com
Although fibrosis is a common pathological feature of most end-stage organ diseases, its pathogenesis remains unclear. There is growing evidence that mitochondrial dysfunction …
RG Jenkins, BB Moore, RC Chambers… - American journal of …, 2017 - atsjournals.org
Numerous compounds have shown efficacy in limiting development of pulmonary fibrosis using animal models, yet few of these compounds have replicated these beneficial effects in …
U Anand, S Jakhmola, O Indari, HC Jha… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly pathogenic novel virus that has caused a massive pandemic called coronavirus disease 2019 (COVID …
KM Usher, S Zhu, G Mavropalias, JA Carrino, J Zhao… - Bone research, 2019 - nature.com
Arthrofibrosis is a fibrotic joint disorder that begins with an inflammatory reaction to insults such as injury, surgery and infection. Excessive extracellular matrix and adhesions contract …
A Nuchin, R Kumar, PA Mahesh - Advances in respiratory medicine, 2021 - mdpi.com
Introduction: The novel coronavirus pandemic has caused significant mortality throughout the world. This study was done as there is scarce data on mortality predictors in severe …